Recombinant Human MTHFD1 cell lysate
Cat.No. : | MTHFD1-1146HCL |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. |
Species : | Human |
Size : | 100 ul |
Storage Buffer : | 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue) |
Applications : | Western Blot; |
Gene Name : | MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase [ Homo sapiens ] |
Official Symbol : | MTHFD1 |
Synonyms : | MTHFD1; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase; MTHFC, MTHFD; C-1-tetrahydrofolate synthase, cytoplasmic; C1-THF synthase; cytoplasmic C-1-tetrahydrofolate synthase; 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase; MTHFC; MTHFD; |
Gene ID : | 4522 |
mRNA Refseq : | NM_005956 |
Protein Refseq : | NP_005947 |
MIM : | 172460 |
UniProt ID : | P11586 |
Chromosome Location : | 14q24 |
Pathway : | C1-unit interconversion, eukaryotes, organism-specific biosystem; C1-unit interconversion, eukaryotes, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of folate and pterines, organism-specific biosystem; Metabolism of vitamins and cofactors, organism-specific biosystem; Metabolism of water-soluble vitamins and cofactors, organism-specific biosystem; |
Function : | ATP binding; formate-tetrahydrofolate ligase activity; hydrolase activity; ligase activity; methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NADP+) activity; methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity; nucleotide binding; oxidoreductase activity; |
Products Types
◆ Recombinant Protein | ||
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MTHFD1-1869P | Recombinant Pongo Abelii MTHFD1 Protein (1-305 aa), His-SUMO-tagged | +Inquiry |
MTHFD1-2185H | Recombinant Human MTHFD1 Protein, MYC/DDK-tagged | +Inquiry |
MTHFD1-5702H | Recombinant Human MTHFD1 Protein, GST-tagged | +Inquiry |
Mthfd1-370M | Recombinant Mouse Mthfd1 Protein, MYC/DDK-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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