Recombinant Human RNF135 cell lysate


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Recombinant Human RNF135 cell lysate

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Cat.No. : RNF135-1519HCL
Description : The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Species : Human
Size : 100 ul
Storage Buffer : 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications : Western Blot;
Gene Name : RNF135 ring finger protein 135 [ Homo sapiens ]
Official Symbol : RNF135
Synonyms : RNF135; ring finger protein 135; E3 ubiquitin-protein ligase RNF135; MGC13061; riplet; RIG-I E3 ubiquitin ligase; L13; MMFD; REUL; Riplet;
Gene ID : 84282
mRNA Refseq : NM_001184992
Protein Refseq : NP_001171921
MIM : 611358
UniProt ID : Q8IUD6
Chromosome Location : 17q11.2
Pathway : Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10, organism-specific biosystem; Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystem; RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem; TRAF3-dependent IRF activation pathway, organism-specific biosystem; TRAF6 mediated IRF7 activation, organism-specific biosystem;
Function : ligase activity; metal ion binding; protein binding; ribonucleoprotein complex binding; ubiquitin-protein ligase activity; zinc ion binding;

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