| Cat.No.: | RNF135-1519HCL |
| Description: | The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| Species: | Human |
| Size: | 100 ul |
| Storage Buffer: | 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue) |
| Applications: | Western Blot; |
| Gene Name: | RNF135 ring finger protein 135 [ Homo sapiens ] |
| Official Symbol: | RNF135 |
| Synonyms: | RNF135; ring finger protein 135; E3 ubiquitin-protein ligase RNF135; MGC13061; riplet; RIG-I E3 ubiquitin ligase; L13; MMFD; REUL; Riplet; |
| Gene ID: | 84282 |
| mRNA Refseq: | NM_001184992 |
| Protein Refseq: | NP_001171921 |
| MIM: | 611358 |
| UniProt ID: | Q8IUD6 |
| Chromosome Location: | 17q11.2 |
| Pathway: | Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10, organism-specific biosystem; Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystem; RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem; TRAF3-dependent IRF activation pathway, organism-specific biosystem; TRAF6 mediated IRF7 activation, organism-specific biosystem; |
| Function: | ligase activity; metal ion binding; protein binding; ribonucleoprotein complex binding; ubiquitin-protein ligase activity; zinc ion binding; |
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