Recombinant Human RNF135 cell lysate RNF135-1519HCL

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Recombinant Human RNF135 cell lysate

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Cat.No. :	RNF135-1519HCL
Description :	The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Species :	Human
Size :	100 ul
Storage Buffer :	1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications :	Western Blot;

Gene Name :	RNF135 ring finger protein 135 [ Homo sapiens ]
Official Symbol :	RNF135
Synonyms :	RNF135; ring finger protein 135; E3 ubiquitin-protein ligase RNF135; MGC13061; riplet; RIG-I E3 ubiquitin ligase; L13; MMFD; REUL; Riplet;
Gene ID :	84282
mRNA Refseq :	NM_001184992
Protein Refseq :	NP_001171921
MIM :	611358
UniProt ID :	Q8IUD6
Chromosome Location :	17q11.2
Pathway :	Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10, organism-specific biosystem; Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystem; RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem; TRAF3-dependent IRF activation pathway, organism-specific biosystem; TRAF6 mediated IRF7 activation, organism-specific biosystem;
Function :	ligase activity; metal ion binding; protein binding; ribonucleoprotein complex binding; ubiquitin-protein ligase activity; zinc ion binding;