Recombinant Human UMOD cell lysate

• Cat.No.: UMOD-1885HCL

Specification

• Description: This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: UMOD uromodulin [ Homo sapiens ]
• Official Symbol: UMOD
• Synonyms: UMOD; uromodulin; uromodulin (uromucoid, Tamm Horsfall glycoprotein); Tamm Horsfall glycoprotein; uromucoid; Tamm-Horsfall glycoprotein; tamm-Horsfall urinary glycoprotein; uromodulin (uromucoid, Tamm-Horsfall glycoprotein); THP; FJHN; HNFJ; THGP; HNFJ1; MCKD2; ADMCKD2
• Gene ID: 7369
• mRNA Refseq: NM_001008389
• Protein Refseq: NP_001008390
• MIM: 191845
• UniProt ID: P07911
• Chromosome Location: 16p12.3
• Function: calcium ion binding