Recombinant Human MAD2L1, His-tagged
Cat.No. : | MAD2L1 -161H |
Product Overview : | Recombinant Human MAD2L1 /MAD2 Protein (rh MAD2L1 /MAD2) Met 1 - Asp 205 (Accession # NP_002349) was produced in E.coli cells. |
- Specification
- Gene Information
- Related Products
Description : | Mitotic arrest deficient 2-like protein 1 (MAD2L1) is also known as Mitotic spindle assembly checkpoint protein MAD2A (HsMAD2), MAD2. MAD2L1 / MAD2 belongs to the MAD2 family. MAD2L1 / MAD2 contains one HORMA domain. MAD2L1 is the component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 / MAD2 is required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization. |
Molecular Mass : | rh MAD2L1 /MAD2 is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 24.3 kDa. The predicted N-terminus is Met 1. DTT-reduced Protein migrates as 24 kDa in SDS-PAGE. |
Endotoxin : | Less than 1.0 EU per μg of the rh MAD2L1 /MAD2 by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC). |
Reconstitution : | See Certificate of Analysis for reconstitution instructions and specific concentrations. |
Gene Name : | MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) [ Homo sapiens ] |
Official Symbol : | MAD2L1 |
Synonyms : | MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast); MAD2 (mitotic arrest deficient, yeast, homolog) like 1; mitotic spindle assembly checkpoint protein MAD2A; HSMAD2; MAD2; MAD2-like protein 1; mitotic arrest deficient 2-like protein 1; mitotic arrest deficient, yeast, homolog-like 1; MAD2 (mitotic arrest deficient, yeast, homolog)-like 1; |
Gene ID : | 4085 |
mRNA Refseq : | NM_002358 |
Protein Refseq : | NP_002349 |
MIM : | 601467 |
UniProt ID : | Q13257 |
Chromosome Location : | 4q27 |
Pathway : | APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; Amplificationof signal from unattachedkinetochores via a MAD2inhibitory signal, organism-specific biosystem; Amplification of signal from the kinetochores, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle Checkpoints, organism-specific biosystem; |
Function : | protein binding; protein homodimerization activity; |
Products Types
◆ Recombinant Protein | ||
MAD2L1-418C | Recombinant Cynomolgus Monkey MAD2L1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Mad2l1-3895M | Recombinant Mouse Mad2l1 Protein, Myc/DDK-tagged | +Inquiry |
MAD2L1-2438R | Recombinant Rhesus Macaque MAD2L1 Protein, His (Fc)-Avi-tagged | +Inquiry |
MAD2L1-2618R | Recombinant Rhesus monkey MAD2L1 Protein, His-tagged | +Inquiry |
MAD2L1-5113C | Recombinant Chicken MAD2L1 | +Inquiry |
◆ Lysates | ||
MAD2L1-4570HCL | Recombinant Human MAD2L1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket