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Active Recombinant Human PI4KB, GST-tagged

Cat.No. : PI4KB-1077H
Product Overview : Full-length recombinant human PI4KB was co-expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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  • Gene Information
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Description : PI4KB is a member of the phosphatidylinositol 4-kinase family (PI4K) and is the first committed step in the production of the second messenger inositol-1,4,5-trisphosphate (PIP3). PI4KB regulates the golgi disintegration/reorganization during mitosis possibly via the phosphorylation of phosphatidylinositol. PI4KB is a type III enzyme that is sensitive to wortmannin and is responsible for regulating the synthesis of agonist-sensitive pools of polyphosphoinositides. PI4KB is critical for glucose-induced insulin secretion due to its capacity to regulate the release of secretory granules. PI4KB inhibits the insulin-stimulated translocation of glucose transporter-4 in mouse adipocytes through its interaction with neuronal calcium sensor-1.
Source : Sf9 insect cells
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity : 37 nmol/min/mg
Molecular Mass : ~120 kDa
Protein length : Full Length
Purity : >90%
Applications : Kinase Assay; Western Blot
Stability : 1 yr at -70oC from date of shipment.
Storage : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1 ug/ul
Gene Name : PI4KB phosphatidylinositol 4-kinase, catalytic, beta [ Homo sapiens ]
Official Symbol : PI4KB
Synonyms : PI4KB; phosphatidylinositol 4-kinase, catalytic, beta; PIK4CB; phosphatidylinositol 4-kinase beta; PI4K BETA; pi4K92; PtdIns 4-kinase beta; type III phosphatidylinositol 4-kinase beta; phosphatidylinositol 4-kinase, wortmannin-sensitive; NPIK; PI4K92; PI4KBETA; PI4K-BETA; PI4KIIIBETA; FLJ30129; DKFZp686O1820
Gene ID : 5298
mRNA Refseq : NM_001198773
Protein Refseq : NP_001185702
MIM : 602758
UniProt ID : Q9UBF8
Chromosome Location : 1q21
Pathway : 3-phosphoinositide biosynthesis; D-myo-inositol (1,4,5)-trisphosphate biosynthesis; Inositol phosphate metabolism
Function : 1-phosphatidylinositol 4-kinase activity; ATP binding; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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