Recombinant Human B2M, His-tagged

• Cat.No.: B2M-76H
• Product Overview: Recombinant Human Beta-2-Microglobulin, fused with N terminal His tag, was expressed in Yeast.

Specification

• Description: Beta-2-Microglobulin (b2M)lies lateral to the α3 chain on the cell surface. Unlike α3, β2 has no transmembrane region. Directly above β2 lies the α1 chain, which itself is lateral to the α2. β2 microglobulin associates not only with the alpha chain of MHC class I molecules, but also with class I-like molecules such as CD1 and Qa.An additional function is association with the HFE protein, together regulating the expression of hepcidin in the liver which targets the iron transporter ferroportin on the cytoplasmic membrane of enterocytes and macrophages for degradation resulting in decreased iron uptake from food and iron release from recycled red blood cells respectively. Loss of this function causes iron excess and hemochromatosis.
• Source: Yeast
• Species: Human
• Tag: His
• Form: Lyophilized from sterile 20mM PB,240mM NaCl,PH6.0.
• Molecular Mass: 12.9kDa
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >95 % as determined by SDS-PAGE
• Applications: Western blotting, ELISA
• Storage: Store it under sterile conditions at -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.Samples are stable for up to twelve months from date of receipt at -80℃.

Gene Information

• Gene Name: B2M beta-2-microglobulin [ Homo sapiens ]
• Official Symbol: B2M
• Synonyms: B2M; beta-2-microglobulin; beta-2-microglobin; beta chain of MHC class I molecules
• Gene ID: 567
• mRNA Refseq: NM_004048
• Protein Refseq: NP_004039
• MIM: 109700
• UniProt ID: P61769
• Chromosome Location: 15q21-q22.2
• Pathway: Adaptive Immune System, organism-specific biosystem; Amyloids, organism-specific biosystem; Antigen Presentation: Folding, assembly and peptide loading of class I MHC, organism-specific biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Antigen processing-Cross presentation, organism-specific biosystem; Class I MHC mediated antigen processing and
• Function: protein binding

Reviews

10/08/2022

To meet the needs of biological activity experiments

01/25/2022

High purity, no impurities.

09/10/2020

The expression level is high, which can meet the daily experimental needs.

Q&As

What is the normal reference range for B2M?

The normal reference range for B2M varies depending on age, gender, weight, individual differences, and other factors. In general, the normal reference range is between 0~3.0mg/L.

Why is B2M reduced?

Causes of reduced B2M include liver and kidney failure, tuberculosis, HIV infection, rheumatoid arthritis, systemic lupus erythematosus and other diseases.

In which diseases does B2M play a role in the diagnosis and treatment?

B2M plays an important role in the diagnosis and prognosis assessment of malignancies such as lymphoma and multiple myeloma. Elevated B2M levels can also indicate worsening or recurrence of certain autoimmune diseases, such as systemic lupus erythematosus.

What are the physiological functions of B2M?

It has a variety of physiological functions in the immune system, including inducing immune response, participating in lymphocyte proliferation and differentiation, regulating immune tolerance, and participating in tumor immune surveillance.

What are the causes of elevated B2M?

The levels can be affected by a variety of factors, such as cancer, inflammation, autoimmune diseases, infections, medications, etc.

How is B2M related to disease?

This is associated with many diseases, including lymphoma, normal stress hydrocephalus, HIV infection, rheumatoid arthritis, nephrotic syndrome, cirrhosis, systemic lupus erythematosus, etc.