Recombinant Human B2M, His-tagged

Cat.No.: B2M-76H
Product Overview: Recombinant Human Beta-2-Microglobulin, fused with N terminal His tag, was expressed in Yeast.
Description: Beta-2-Microglobulin (b2M)lies lateral to the α3 chain on the cell surface. Unlike α3, β2 has no transmembrane region. Directly above β2 lies the α1 chain, which itself is lateral to the α2. β2 microglobulin associates not only with the alpha chain of MHC class I molecules, but also with class I-like molecules such as CD1 and Qa.An additional function is association with the HFE protein, together regulating the expression of hepcidin in the liver which targets the iron transporter ferroportin on the cytoplasmic membrane of enterocytes and macrophages for degradation resulting in decreased iron uptake from food and iron release from recycled red blood cells respectively. Loss of this function causes iron excess and hemochromatosis.
Source: Yeast
Species: Human
Tag: His
Form: Lyophilized from sterile 20mM PB,240mM NaCl,PH6.0.
Molecular Mass: 12.9kDa
Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
Purity: >95 % as determined by SDS-PAGE
Applications: Western blotting, ELISA
Storage: Store it under sterile conditions at -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.Samples are stable for up to twelve months from date of receipt at -80℃.
Gene Name: B2M beta-2-microglobulin [ Homo sapiens ]
Official Symbol: B2M
Synonyms: B2M; beta-2-microglobulin; beta-2-microglobin; beta chain of MHC class I molecules;
Gene ID: 567
mRNA Refseq: NM_004048
Protein Refseq: NP_004039
MIM: 109700
UniProt ID: P61769
Chromosome Location: 15q21-q22.2
Pathway: Adaptive Immune System, organism-specific biosystem; Amyloids, organism-specific biosystem; Antigen Presentation: Folding, assembly and peptide loading of class I MHC, organism-specific biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Antigen processing-Cross presentation, organism-specific biosystem; Class I MHC mediated antigen processing and
Function: protein binding;

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