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Recombinant Human SELP, Fc-tagged

Cat.No.: SELP-208H
Product Overview: A DNA sequence encoding the human SELP extracellular domain (Met 1-Ala 771) was fused with the Fc region of human IgG1 at the C-terminus.
Description: This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented.
Source: Human Cells
Species: Human
Tag: Fc
Predicted N Terminal: Trp 42
Form: Lyophilized from sterile PBS, pH 7.4
Bio-activity: Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. When 5 x 104 cells/well are added to SELP/Fc Chimera coated plates (10 μg/mL with 100 μL/well), > 80% cells will adhere for 1 hour incubation at 37?.
Molecular Mass: The recombinant human SELP/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 971 amino acids and has a predicted molecular mass of 107 kDa. The apparent molecular mass of the reduced monomer is approximately 130-150 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Purity: > 85 % as determined by SDS-PAGE
Stability: Samples are stable for up to twelve months from date of receipt at -70?
Storage: Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products.
Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Gene Name: SELP selectin P (granule membrane protein 140kDa, antigen CD62) [ Homo sapiens ]
Official Symbol: SELP
Synonyms: P-SEL; Platelet Alpha-Granule Membrane Protein; CD62; CD62P; Granulocyte Membrane Protein GRMP; GMP140; LECAM-3; SELP; FLJ45155; GRMP; PADGEM; PSEL; selectin P (granule membrane protein 140kDa, antigen CD62); LECAM3; selectin P; OTTHUMP00000032609; granulocyte membrane protein; platelet alpha-granule membrane protein; leukocyte-endothelial cell adhesion molecule 3; CD62 antigen-like family member P; CD62P antigen; Granule membrane protein 140; selectin P (granule membrane protein 140kD, antigen CD62).
Gene ID: 6403
mRNA Refseq: NM_003005
Protein Refseq: NP_002996
MIM: 173610
UniProt ID: P16109
Chromosome Location: 1q22-q25
Pathway: Cell adhesion molecules (CAMs); Cell surface interactions at the vascular wall; IL-3 Signaling Pathway
Function: calcium-dependent protein binding; glycoprotein binding; glycosphingolipid binding

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