Recombinant Human CAPN2, MYC/DDK-tagged CAPN2-123H

Recombinant Human CAPN2, MYC/DDK-tagged


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Recombinant Human CAPN2, MYC/DDK-tagged

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Cat.No. : CAPN2-123H
Product Overview : Recombinant Human CAPN2, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.
Description : The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene.
Source : HEK293 cells
Species : Human
Molecular Mass : 79.8 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : CAPN2 calpain 2, (m/II) large subunit [ Homo sapiens (human) ]
Official Symbol : CAPN2
Synonyms : CAPN2; calpain 2, (m/II) large subunit; calpain-2 catalytic subunit; CANPL2; CANPml; mCANP; CANP 2; M-calpain; calpain M-type; millimolar-calpain; calpain-2 large subunit; calpain 2, large subunit; calpain large polypeptide L2; calpain, large polypeptide L2; calpain 2, large [catalytic] subunit; calcium-activated neutral proteinase 2; CANP2; FLJ39928
Gene ID : 824
mRNA Refseq : NM_001748
Protein Refseq : NP_001739
MIM : 114230
UniProt ID : P17655
Chromosome Location : 1q41-q42
Pathway : Alzheimers Disease; ErbB1 downstream signaling; Protein processing in endoplasmic reticulum
Function : calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; cysteine-type peptidase activity

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