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Recombinant Human EFNA3, His-tagged

Cat.No.: EFNA3-155H
Product Overview: Recombinant Human Ephrin A3 / EFNA3 Protein (rh Ephrin-A3 / EFNA3) Gln 23 - Ser 213 (Accession # AAI10407) was produced in human 293 cells (HEK293).
Description: Ephrin-A3 (Ephrin A3) is also known as EFL-2, EHK1 ligand, EHK1-L, EPH-related receptor tyrosine kinase ligand 3, EFL2, EPLG3 and LERK3,which comprises the largest subfamily of receptor protein-tyrosine kinases (RTKs), and has been involved in a variety of biological processes, especially in the nervous system and in erythropoiesis, such as axon guidance and topographic map formation, synaptic plasticity, angiogenesis, and meanwhile have possible contributions to tumor growth and metastasis. Ephrin A3 is cell surface GPI-bound ligand for Eph receptors and belongs to the family of receptor tyrosine kinases. Ephrin can bind promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.
Source: HEK293
Species: Human
Tag: His
Predicted N Terminal: Gln 23
Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Molecular Mass: rh Ephrin-A3 / EFNA3 is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 22.2 kDa. The predicted N-terminus is Gln 23. DTT-reduced Protein migrates as 40-45 kDa in SDS-PAGE due to glycosylation.
Endotoxin: Less than 1.0 EU per μg of the rh Ephrin-A3 / EFNA3 by the LAL method.
Purity: >90% as determined by SDS-PAGE.
Applications: Bio-Markers
Storage: Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).
Gene Name: EFNA3 ephrin-A3 [ Homo sapiens ]
Official Symbol: EFNA3
Synonyms: EFNA3; ephrin-A3; EPLG3; Ehk1 L; LERK3; EFL-2; LERK-3; EHK1 ligand; ligand of eph-related kinase 3; eph-related receptor tyrosine kinase ligand 3; EFL2; Ehk1-L;
Gene ID: 1944
mRNA Refseq: NM_004952
Protein Refseq: NP_004943
MIM: 601381
UniProt ID: P52797
Chromosome Location: 1q21-q22
Pathway: Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; EPHA forward signaling, organism-specific biosystem;
Function: ephrin receptor binding; transmembrane-ephrin receptor activity;

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