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Recombinant Human IFNAR2, His-tagged

Cat.No.: IFNAR2-156H
Product Overview: Recombinant Human IFNAR2 /IFNABR Protein (rh IFNAR2 /IFNABR) Ile 27 - Lys 243 (Accession # NP_997467) was produced in human 293 cells (HEK293).
Description: Interferon alpha/beta receptor 2 (IFNAR2) is also known as IFN-alpha binding protein, IFN-alpha/beta receptor 2, Type I interferon receptor 2, IFNABR and IFNARB, which is a single-pass type I membrane protein and belongs to the type II cytokine receptor family. IFNAR2 can associate with IFNAR1 to form the type I interferon receptor. IFNAR2 is a receptor for interferons alpha and beta.IFNAR2 involves in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 of IFNAR2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 of IFNAR2 is a potent inhibitor of type I IFN receptor activity.Genetic variations in IFNAR2 influence susceptibility to hepatitis B virus (HBV) infection.
Source: HEK293
Species: Human
Tag: His
Predicted N Terminal: Ile 27
Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Molecular Mass: rh IFNAR2 /IFNABR is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 25.6 kDa. The predicted N-terminus is Ile 27. DTT-reduced Protein migrates as 40-50 kDa in SDS-PAGE due to glycosylation.
Endotoxin: Less than 1.0 EU per μg of the rh IFNAR2 /IFNABR by the LAL method.
Purity: >95% as determined by SDS-PAGE.
Applications: Bio-Markers
Storage: Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).
Gene Name: IFNAR2 interferon (alpha, beta and omega) receptor 2 [ Homo sapiens ]
Official Symbol: IFNAR2
Synonyms: IFNAR2; interferon (alpha, beta and omega) receptor 2; IFNABR; interferon alpha/beta receptor 2; IFN-R-2; IFN-alpha binding protein; IFN-alpha/beta receptor 2; type I interferon receptor 2; interferon alpha binding protein; human interferon alpha/beta receptor; interferon-alpha/beta receptor beta chain; IFN-R; IFNARB; IFN-alpha-REC;
Gene ID: 3455
mRNA Refseq: NM_000874
Protein Refseq: NP_000865
MIM: 602376
UniProt ID: P48551
Chromosome Location: 21q22.1
Pathway: Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Downstream signaling in naive CD8+ T cells, organism-specific biosystem; Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem; Herpes simplex infection, organism-specific biosystem;
Function: protein binding; protein kinase binding; receptor activity; type I interferon binding; type I interferon receptor activity;

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