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Recombinant Cynomolgus CD86, His-tagged

Cat.No.: CD86-171C
Product Overview: Recombinant Cynomolgus CD86 /B7-2 Protein (Cynomolgus CD86) Ala 18 - His 239 (Accession # Q9BDM4) was produced in human 293 cells (HEK293).
Description: Cluster of Differentiation 86 (CD86) is also known as B-lymphocyte activation antigen B7-2, is a type I membrane protein that is a member of the immunoglobulin superfamily, and is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B72 is expressed at low levels on monocytes and can be upregulated through interferon γ. CD86 is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells. Recent study has revealed that B7-2 promotes the generation of a mature APC repertoire and promotes APC function and survival. Furthermore, the B7 proteins are also involved in innate immune responses by activating NF-κB-signaling pathway in macrophages. CD86 thus is regarded as a promising candidate for immune therapy. CD86+ macrophages in Hodgkin lymphoma patients are an independent marker for potential nonresponse to firstline-therapy.
Source: HEK293
Species: Cynomolgus
Tag: His
Predicted N Terminal: Ala 18
Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Molecular Mass: Cynomolgus CD86 is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 27.3 kDa. The predicted N-terminus is Ala 18. DTT-reduced Protein migrates as 50-80 kDa in SDS-PAGE due to glycosylation.
Endotoxin: Less than 1.0 EU per μg of the Cynomolgus CD86 by the LAL method.
Purity: >95% as determined by SDS-PAGE.
Applications: CD Antigens
Storage: Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).
Gene Name: CD86?CD86 molecule [?Macaca fascicularis?(crab-eating macaque) ]
Official Symbol: CD86
Synonyms: CD86; CD86 molecule
Gene ID: 102147235
mRNA Refseq: XM_005547999
Protein Refseq: ?XP_005548056
Chromosome Location: 2
Pathway: Autoimmune thyroid disease; Graft-versus-host disease; Intestinal immune network for IgA production

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