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Active Recombinant Human KDM6A protein, FLAG-tagged

Cat.No. : KDM6A-84H
Product Overview : Recombinant Human KDM6A (a.a: 1-1401) fussed with FLAG tag at N-terminal was expressed in Insect cells.
  • Specification
  • Gene Information
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Description : This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. Multiple alternatively spliced transcript variants have been found for this gene.
Source : Insect Cells
Species : Human
Tag : FLAG
Form : 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween20, 20% glycerol, 80 μg/ml FLAG peptide.
Bio-activity : 0.6 pmol/min/μg
Molecular Mass : 155 kDa
Applications : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Stability : At least 6 months at –80 centigrade. Storing diluted enzyme is not recommended, if necessary, use carrier protein (BSA 0.1 – 0.5%). Avoid freeze/thaw cycles.
Gene Name : KDM6A lysine (K)-specific demethylase 6A [ Homo sapiens ]
Official Symbol : KDM6A
Synonyms : UTX; KABUK2; bA386N14.2; lysine-specific demethylase 6A; bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX)); histone demethylase UTX; ubiquitously transcribed tetratricopeptide repeat protein X-linked; ubiquitously-transcribed TPR gene on the X chromosome
Gene ID : 7403
mRNA Refseq : NM_021140
Protein Refseq : NP_066963
MIM : 300128
UniProt ID : O15550
Chromosome Location : Xp11.2
Pathway : Chromatin modifying enzymes, organism-specific biosystem; Chromatin organization, organism-specific biosystem; HDMs demethylate histones, organism-specific biosystem
Function : RNA polymerase II core promoter proximal region sequence-specific DNA binding; dioxygenase activity; histone demethylase activity (H3-K27 specific)

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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