Native Human Pro-MMP-8

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Native Human Pro-MMP-8

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Cat.No. : MMP8-89H
Description : Human neutrophil collagenase (HNC) has been purified from extracts of fresh and outdated buffy coats and from exudates of phorbol myristate acetate-stimulated neutrophils. The MMP-8 present in the starting material can either be latent or active, or have an app. relative molecular mass of 75-kDa and/or 58-kDa. The rather complex pattern of activation of the latent 58-kDa and 75-kDa species by trypsin, organomercurials and oxidants has been investigated. MMP-8 was shown to preferentially hydrolyze type I over type II, and type III collagens in solution and to be a glycoprotein that contains complex N-linked oligosaccharides leading to multiple forms of MMP-8 in SDS-PAGE. The action of endoglycosidase on the latent 58-kDa form produces 42/40-kDa species (Gao et al. 1992, Mallya et al. 1990). This indicates that MMP-8 is an N-linked, complex glycoprotein that appears to be glycosylated at multiple sites
Source : Human neutrophil granulocytes (Buffy Coat)
Species : Human
Form : Liquid
Molecular Mass : 40/42 kDa
Usage : For Research Use Only! Not For Use in Humans.
Notes : Centrifuge the vial prior to opening
Storage : -80°C
Storage Buffer : In 50 mM Tris-HCl, pH 7; 200 mM NaCl; 5 mM CaCl?; 1 μM ZnCl?; 0.05% Brij 35; 0,05% NaN?
Shipping : Dry Ice
Figure :

Gene Name : MMP8 matrix metallopeptidase 8 (neutrophil collagenase) [ Homo sapiens ]
Official Symbol : MMP8
Synonyms : MMP8; matrix metallopeptidase 8 (neutrophil collagenase); CLG1, matrix metalloproteinase 8 (neutrophil collagenase); neutrophil collagenase; PMNL collagenase; matrix metalloproteinase-8; matrix metalloproteinase 8 (neutrophil collagenase); HNC; CLG1; MMP
Gene ID : 4317
mRNA Refseq : NM_002424
Protein Refseq : NP_002415
MIM : 120355
UniProt ID : P22894
Chromosome Location : 11q21-q22
Pathway : Activation of Matrix Metalloproteinases, organism-specific biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Extracellular matrix organization, organism-specific biosystem; Matrix Metalloproteinases, organism-specific biosystem;
Function : calcium ion binding; metalloendopeptidase activity; peptidase activity; serine-type endopeptidase activity; zinc ion binding;

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