"TIMP1" Related Products

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Native Bovine Thrombin

Cat.No.: TIMP1-91B
Description: Thrombin enzyme (Activated Factor IIa) is an important clotting promoter that controls the transformation of soluble fibrinogen to insoluble active fibrin strands. Thrombin is a coagulation protein and a serine protease (EC 3.4.21.5) that catalyzes many coagulation-related reactions. Thrombin triggers factor-XI, factor-V, Factor-XIII and factor-VIII. Thrombin endorses platelet activation, using activation of protease-activated receptors on the platelet. As a result of its high proteolytic specificity, thrombin has become an important biochemical protein. The thrombin cleavage site (Leu-Val-Pro-Arg-Gly-Ser) is widely used in linker regions of recombinant fusion protein constructs. After the purification of the fusion protein, thrombin is used to cleave between the Arginine and Glycine residues of the cleavage site, efficiently removing the purification tag from the protein of interest with a high degree of specificity.
Source: Bovine plasma
Species: Bovine
Form: Lyophilized
Bio-activity: 90-250 U/mg of lyophilized powder.
Molecular Mass: 37 kDa
Purity: Purity by SDS-PAGE: ≥98%
Usage: For Research Use Only! Not For Use in Humans.
Notes: Centrifuge the vial prior to opening
Storage: -20°C
Storage Buffer: Sterile filtered and lyophilized with Mannitol and Sodium Chloride.
Reconstitution: Reconstitute in sterile water (100 U/ml) with 0.9% NaCl. It forms a clear solution.
Shipping: Gel pack
Gene Name: TIMP1 TIMP metallopeptidase inhibitor 1 [ Bos taurus ]
Official Symbol: TIMP1
Synonyms: metalloproteinase inhibitor 1; EG-1TIMP-1embryogenin-1; tissue inhibitor of metalloproteinases 1; tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor)
Gene ID: 282092
mRNA Refseq: NM_174471
Protein Refseq: NP_776896
UniProt ID: P20414
Chromosome Location: chromosome: X
Pathway: Activation of Matrix Metalloproteinases, organism-specific biosystem; Hemostasis, organism-specific biosystem; Platelet degranulation, organism-specific biosystem
Function: cytokine activity; metal ion binding; metalloendopeptidase inhibitor activity

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