"TIMP1" Related Products


Native Human TIMP-1

Cat.No.: TIMP1-92H
Description: The tissue inhibitor of metalloproteinases (TIMP-1) is a glycoprotein with a molecular mass of about 28-kDa. The secreted protein consists of 184 amino acids, six disuilfide bonds and two glycosylation sites containing N-linked oligosaccharides. TIMP-1 specifically inhibits the extracellular-matrix-egradingmetalloproteinases such as collagenase, gelatinase and stromelysin. It has no activity on mammalian membrane metallo-proteinases, procollagen peptidase, or on bacterial metalloproteinases such as thermolysin
Source: Human neutrophil granulocytes (Buffy Coat)
Species: Human
Form: Liquid
Molecular Mass: 28.0 kDa
Purity: Purity by SDS-PAGE: ≥92%
Usage: For Research Use Only! Not For Use in Humans.
Notes: Centrifuge the vial prior to opening
Storage: -80°C
Storage Buffer: In 50 mM Tris-HCl, pH 7; 200 mM NaCl; 5 mM CaCl?; 1 μM ZnCl?; 0.05% Brij 35; 0,05% NaN?
Shipping: Dry Ice
Gene Name: TIMP1 TIMP metallopeptidase inhibitor 1 [ Homo sapiens ]
Official Symbol: TIMP1
Synonyms: TIMP1; TIMP metallopeptidase inhibitor 1; CLGI, TIMP, tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor); metalloproteinase inhibitor 1; EPO; TIMP-1; collagenase inhibitor; erythroid potentiating activity; er
Gene ID: 7076
mRNA Refseq: NM_003254
Protein Refseq: NP_003245
MIM: 305370
UniProt ID: P01033
Chromosome Location: Xp11.3-p11.23
Pathway: Activation of Matrix Metalloproteinases, organism-specific biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Extracellular matrix organization, organism-specific biosystem; Hemostasis, organism-specific biosystem; IL6-mediated signaling events, organism-specific biosystem; Matrix Metalloproteinases, organism-specific biosystem; Platelet activation, signaling and aggregation, organism-specific biosystem;
Function: enzyme inhibitor activity; metal ion binding; metalloendopeptidase inhibitor activity; metalloendopeptidase inhibitor activity; protein binding;

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