"C4BPB" Related Products

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Native Human C4b-Binding Protein

Cat.No.: C4BPB-184H
Description: C4b-binding protein is a regulatory protein of the Complement Cascade that possesses decay-accelerating activity. Circulating in plasma, it aids in the control of fluid-phase and surface-associated activation of C3 and C5 and serves as a cofactor to Factor 1 in the proteolytic degradation of C4b. There are three isoforms circulating in plasma; 7 alpha chains and 1 Beta chain, 6 alpha chains and 1 Beta chain, and 7 alpha chains without a Beta chain. The 7 alpha, 1 Beta form is the most abundant. All C4BP molecules that contain a Beta chain circulate in plasma in a high-affinity, calcium-dependent complex with vitamin K-dependent, anticoagulant Protein S.
Source: Human Plasma
Species: Human
Form: Frozen
Molecular Mass: ~ 570,000 (whole molecule)~ 70-75,000 (alpha chains)~ 40-45,000 (beta chain)
Purity: >= 95% by SDS-PAGE
Usage: For research use only
Quality Control Test: Shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
Stability: >1 year
Storage: <=>
Storage Buffer: 10 mM Tris, pH 7.4, with 100 mM NaCl+ 0.05% NaN3
Gene Name: C4BPB complement component 4 binding protein, beta [ Homo sapiens ]
Official Symbol: C4BPB
Synonyms: C4BPB; complement component 4 binding protein, beta; C4BP, complement component 4 binding protein, beta; C4b-binding protein beta chain; C4b binding protein; beta chain; complement component 4 binding protein; C4BP;
Gene ID: 725
mRNA Refseq: NM_000716
Protein Refseq: NP_000707
MIM: 120831
UniProt ID: P20851
Chromosome Location: 1q32
Pathway: Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Complement cascade, organism-specific biosystem; FOXA1 transcription factor network, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; Pertussis, organism-specific biosystem;

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