Native Human GC-Globulin


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Native Human GC-Globulin

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Cat.No. : GC-198H
Description : An alpha 2 glycoprotein composed of a single polypeptide chain and present in plasma at levels of 20-55 mg/100 ml. It functions in the binding and transport of vitamin D and may also play an important role in actin homeostatis since it has been shown to bind monomeric actin with high affinity. GC-globulin also binds membranes of both circulating B and T lymphocytes. Clinically, concentrations are reduced in patients with severe liver diseases. GC-globulin may also play an important role in the mechanism of the osteomalacia that occurs with Itai-Itai disease.
Source : Human Plasma
Species : Human
Form : Lyophilized
Molecular Mass : 56, 000
Purity : >= 95% by SDS-PAGE
Usage : For research use or for use in further manufacturing.
Quality Control Test : Shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
Stability : >1 year
Storage : <=>
Storage Buffer : 20 mM NaH2PO4, 0.15 M NaCl pH 7.4
Gene Name : GC group-specific component (vitamin D binding protein) [ Homo sapiens ]
Official Symbol : GC
Synonyms : GC; group-specific component (vitamin D binding protein); vitamin D-binding protein; DBP; hDBP; VDBP; VDB; gc-globulin; vitamin D-binding alpha-globulin; GRD3; VDBG; DBP/GC;
Gene ID : 2638
mRNA Refseq : NM_000583
Protein Refseq : NP_000574
UniProt ID : P02774
Chromosome Location : 4q12-q13
Pathway : Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Metabolism of steroid hormones and vitamins A and D, organism-specific biosystem; Vitamin D (calciferol) metabolism, organism-specific biosystem;
Function : actin binding; vitamin D binding; vitamin transporter activity;

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