Native Human GC-Globulin
| Cat.No. : | GC-198H |
- Specification
- Gene Information
- Related Products
| Description : | An alpha 2 glycoprotein composed of a single polypeptide chain and present in plasma at levels of 20-55 mg/100 ml. It functions in the binding and transport of vitamin D and may also play an important role in actin homeostatis since it has been shown to bind monomeric actin with high affinity. GC-globulin also binds membranes of both circulating B and T lymphocytes. Clinically, concentrations are reduced in patients with severe liver diseases. GC-globulin may also play an important role in the mechanism of the osteomalacia that occurs with Itai-Itai disease. |
| Source : | Human Plasma |
| Species : | Human |
| Form : | Lyophilized |
| Molecular Mass : | 56, 000 |
| Purity : | >= 95% by SDS-PAGE |
| Usage : | For research use or for use in further manufacturing. |
| Quality Control Test : | Shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests. |
| Stability : | >1 year |
| Storage : | <=> |
| Storage Buffer : | 20 mM NaH2PO4, 0.15 M NaCl pH 7.4 |
| Gene Name : | GC group-specific component (vitamin D binding protein) [ Homo sapiens ] |
| Official Symbol : | GC |
| Synonyms : | GC; group-specific component (vitamin D binding protein); vitamin D-binding protein; DBP; hDBP; VDBP; VDB; gc-globulin; vitamin D-binding alpha-globulin; GRD3; VDBG; DBP/GC; |
| Gene ID : | 2638 |
| mRNA Refseq : | NM_000583 |
| Protein Refseq : | NP_000574 |
| UniProt ID : | P02774 |
| Chromosome Location : | 4q12-q13 |
| Pathway : | Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Metabolism of steroid hormones and vitamins A and D, organism-specific biosystem; Vitamin D (calciferol) metabolism, organism-specific biosystem; |
| Function : | actin binding; vitamin D binding; vitamin transporter activity; |
Products Types
| ◆ Recombinant Protein | ||
| GC-4785H | Recombinant Human GC Protein, GST-tagged | +Inquiry |
| gC-1699H | Recombinant HSV-1 gC Protein | +Inquiry |
| GC-3500M | Recombinant Mouse GC Protein, His (Fc)-Avi-tagged | +Inquiry |
| GC-1222H | Recombinant Human GC Protein, His-tagged | +Inquiry |
| GC-971H | Recombinant Human GC Protein, His (Fc)-Avi-tagged | +Inquiry |
| ◆ Native Protein | ||
| GC-29857TH | Native Human GC | +Inquiry |
| GC-524H | Native Human GC protein | +Inquiry |
| ◆ Lysates | ||
| GC-5995HCL | Recombinant Human GC 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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