Native Bovine Lactadherin

• Cat.No.: MFGE8-288B

Specification

• Description: Lactadherin is a widely distributed glycoprotein (~ 50 kDa), which was originally characterized due to its association with milk fat/lipid globule membranes. Synonymous names are PAS-6/7, bovine-associated mucoprotein, BA-46, P47, and MFG-E8. Structural hallmarks of lactadherin are the presence of two epidermal growth factor (EGF) homology domains (with an RGD peptide motif in the second EGF domain), and two C domains sharing homology with the discoidin family of lectin domains including the phospholipid-binding domains of blood clotting factors V and VIII. Lactadherin shows preferential binding to phosphatidylserine (L-form) in a calcium independent manner.
• Source: Milk, also secreted by stimulated macrophages, vascular smooth muscle, endothelial cells
• Species: Bovine
• Form: 70 mM Sodium Phosphate, pH 7.0
• Molecular Mass: 52 kDa and 47 kDa
• Purity: >95% by SDS-PAGE. NOT tissue/cell culture grade. Not tested for endotoxin.
• Characteristic: Extinction coefficient:16.5, Plasma concentration: unknown in normal adults, measurable in women with metastatic breast cancer, measurable in newborn calves after milk meal, Percent carbohydrate: 6%, 13% for glycosylation variants , Structure:single chain with two EGF domains and two C domains. The mouse isoform contains a central proline rich region and the human molecule contains a single EGF domain
• Storage: -70°C

Gene Information

• Gene Name: MFGE8 milk fat globule-EGF factor 8 protein [ Bos taurus ]
• Official Symbol: MFGE8
• Synonyms: lactadherin; BP47; MFGM; SED1; MFG-E8; MGP57/53; components 15/16; PAS-6/PAS-7 glycoprotein; sperm surface protein SP47
• Gene ID: 281913
• mRNA Refseq: NM_176610
• Protein Refseq: NP_788783
• UniProt ID: Q95114
• Chromosome Location: chromosome: 21
• Pathway: Amyloids, organism-specific biosystem; Disease, organism-specific biosystem