Active Recombinant Human ATXN3L, His-tagged
Cat.No. : | ATXN3L-174H |
Product Overview : | Recombinant human ATXN3L (amino acid residues 1-355), fused with N-terminal His, was expressed in E.coli. |
- Specification
- Gene Information
- Related Products
Description : | There are two main classes of DUB; cysteine proteases and metalloproteases. Ataxin-3L is a cysteine protease and a member of the Machado-Joseph Domain (MJD) enzyme family. Cloning of the human gene was first described by Gerhard et al. (2004). Machado–Joseph disease (MJD), the most common form of spinocerebellar ataxia worldwide, is a progressive and ultimately fatal neurodegenerative disorder caused by polyQ expansion in ataxin-3, a conserved and ubiquitous protein known to bind polyubiquitin chains and to function as a deubiquitylating enzyme. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | 50 mM HEPES pH 7.5, 150 mM sodium chloride, 2 mM dithiothreitol, 10% glycerol |
Bio-activity : | Deubiquitylase Enzyme Assay: The activity of His-Ataxin-3L was validated by determining the increase in fluorescence measured as a result of the enzyme catalysed cleavage of the fluorogenic substrate Ubiquitin-Rhodamine110-Glycine generating Ubiquitin and Rhodamine110-Glycine. Incubation of the substrate in the presence or absence of His-Ataxin-3L was compared confirming the deubiquitylating activity of His-Ataxin-3L. |
Molecular Mass : | ~43 kDa |
Purity : | >92% by SDS-PAGE |
Storage : | 12 months at -70°C. Avoid multiple freeze/thaw cycles. |
Concentration : | 0.5 mg/ml |
Gene Name : | ATXN3L ataxin 3-like [ Homo sapiens ] |
Official Symbol : | ATXN3L |
Synonyms : | ataxin 3-like; ATX3L; MJDL; EC 3.4.19.12; Machado-Joseph disease protein 1-like; EC 3.4.22; putative ataxin-3-like protein |
Gene ID : | 92552 |
mRNA Refseq : | NM_001135995.1 |
Protein Refseq : | NP_001129467.1 |
UniProt ID : | B4DYC7 |
Chromosome Location : | Xp22.2 |
Pathway : | Protein processing in endoplasmic reticulum, organism-specific biosystem; Protein processing in endoplasmic reticulum, conserved biosystem |
Function : | omega peptidase activity; ubiquitin-specific protease activity |
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◆ Recombinant Protein | ||
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ATXN3L-164H | Recombinant Human ATXN3L, His-tagged | +Inquiry |
ATXN3L-10070H | Recombinant Human ATXN3L, GST-tagged | +Inquiry |
ATXN3L-203H | Active Recombinant Human ATXN3L protein, His-tagged | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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