"EZH2" Related Products

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Recombinant Human EZH2, His-GST-tagged

Cat.No.: EZH2-998H
Product Overview: Recombinant Human EZH2(amino acids 2-end), fused with N-terminal His-GST tag, was expressed in a Sf9 baculovirus expression system.
Description: This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.
Source: sf9 Cells
Species: Human
Tag: His-GST
Form: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 16 mM glutathione and 20% Glycerol.
Molecular Mass: 114 kDa
Purity: Purity>65%
Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage: >6 months at –80°C
Gene Name: EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit [ Homo sapiens (human) ]
Official Symbol: EZH2
Synonyms: EZH2; enhancer of zeste homolog 2 (Drosophila); enhancer of zeste (Drosophila) homolog 2; histone-lysine N-methyltransferase EZH2; ENX 1; EZH1; KMT6; KMT6A
Gene ID: 2146
mRNA Refseq: NM_004456
Protein Refseq: NP_004447
MIM: 601573
UniProt ID: Q15910
Chromosome Location: 7q35-q36
Pathway: Cellular Senescence; Epigenetic regulation of gene expression; MicroRNAs in cancer
Function: RNA binding; histone methyltransferase activity; histone methyltransferase activity (H3-K27 specific)

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