Recombinant Chicken FAP Protein, K30-E759, N-His tagged
Cat.No. : | FAP-4123C |
Product Overview : | Recombinant Chicken FAP protein (K30-E759) with N-His tag was expressed in HEK293. |
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Description : | The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Source : | HEK293 |
Species : | Chicken |
Tag : | N-His |
Protein length : | K30-E759 |
Molecular Mass : | 85 kDa |
AA Sequence : | HHHHHHHHKVVTTVDGPRALTLDDY LNGNFQYKTYFPYWVSDSEYLHQNQ EDDIILFNVDMNYLTTIMTNSTMKQ VNASNYVMSSDKYFIALESNYSKLW RYSYTASYHIYDLIYGGFVTENQLP HKIQYISWSPVGHKLAYVYQNNIYL KQSPREAPIKLTSDGKENEIFNGIP DWVYEEEMLATKYALWWSPSGKYLA YVQFNDSDIPVIEYSYFGEDQYPRK IIIPYPKAGAKNPTVKVFIVDTTNI EAFGPKEVPVPAVIASSDHYFTWLT WVTDSRVGVQWLKRIQNFSVLAICD FKENSNTWDCPENQQHIEESQTGWA GGFFVSAPYFTSDGSSYYKIFSDKN GYKHIHYINGSVENAIQITSGEWEA IYIFRVTNDAIFYSSNEFEGYPGRR NIYKISIGSKPIRKLCITCNLRKER CQYYTARFSERSKYYALICYGPGIP ISTLFENESDRELRILEDNQELQSA LQEIILPKEEINKLEVDGITLWYKM LIPPQFDRSKKYPLLIQVYGGPCSQ NVKHTFSISWITYLASKEGIIVALV DGRGTAYQGDKILHAVYRRLGVYEV EDQISAVKKFIEMGFIDEKRIAIWG WSYGGYVTSLALGSGSGVFKCGIAV APVSSWEYYASIYTERFMGLPVESD NLEHYKNSTVMARAKNFQNVEYLLI HGTADDNVHFQNSAQIAKALVNAQV DFQAMWYTDQNHGIPGLSSKHLYTH MTHFLKQCFSLSE |
Endotoxin : | < 1 EU/μg by LAL |
Purity : | > 95% by SDS-PAGE |
Storage : | Store it under sterile conditions at -20 to -80 centigade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Concentration : | 0.38 mg/mL by BCA |
Storage Buffer : | Sterile PBS, pH7.4 |
Gene Name : | FAP fibroblast activation protein alpha [ Gallus gallus (chicken) ] |
Official Symbol : | FAP |
Synonyms : | FAP; fibroblast activation protein alpha; prolyl endopeptidase FAP; EC 3.4.14.5; EC 3.4.21.26 |
Gene ID : | 424186 |
mRNA Refseq : | NM_001193639 |
Protein Refseq : | NP_001180568 |
UniProt ID : | A0A8V0ZGU9 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionFAP can suppress the immune response by modulating the activity of certain immune cells, creating an immunosuppressive tumor microenvironment.
High levels of FAP expression in tumors have been associated with poor prognosis, making it a potential prognostic marker for certain cancers.
Yes, several clinical trials are investigating the safety and efficacy of FAP-targeted therapies in various cancer types.
FAP-targeted therapies are being explored for conditions such as fibrotic diseases and rheumatoid arthritis, extending its potential clinical applications.
Molecular imaging techniques, such as positron emission tomography (PET), can be employed to visualize FAP expression in tumors noninvasively.
Customer Reviews (3)
Write a reviewIt enables accurate detection and quantification of FAP protein levels in samples, providing crucial insights into its expression, regulation, and potential functional changes under different experimental conditions.
FAP protein is highly recommended for researchers due to its excellent performance in various assays, particularly in Western blotting (WB) experiments, and its applicability in protein electron microscopy structure analysis.
FAP protein is highly recommended for researchers, as it demonstrates excellent performance in WB experiments and has proven useful in protein electron microscopy structure analysis.
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