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Recombinant Chicken ARNTL2

Cat.No. : ARNTL2-5709C
Product Overview : Recombinant Chicken ARNTL2 full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Chicken
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC.
Storage Buffer : PBS buffer
Gene Name : ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2 [ Gallus gallus (chicken) ]
Official Symbol : ARNTL2
Gene ID : 373925
Protein Refseq : NP_989464
UniProt ID : Q8QGQ7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (14)

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What impact does ARNTL2 dysfunction have on metabolism? 04/15/2023

The specific impact of ARNTL2 dysfunction on metabolism is not yet well-understood. However, studies have suggested that ARNTL2 disruptions can lead to metabolic dysregulation, including altered glucose metabolism and lipid metabolism. ARNTL2 may play a role in regulating metabolism through its effects on circadian rhythms and the expression of metabolic genes.

Can ARNTL2 expression be influenced by hormonal signals? 10/09/2022

Yes, hormonal signals can influence ARNTL2 expression. Hormones such as glucocorticoids, insulin, and growth hormone have been shown to regulate ARNTL2 gene expression. These hormonal signals can modulate circadian rhythms and influence the expression of circadian clock genes, including ARNTL2.

What are potential research directions for ARNTL2? 06/07/2021

Some potential research directions for ARNTL2 include elucidating its molecular mechanisms in circadian rhythm regulation, identifying its specific target genes, investigating its role in different tissues and cell types, exploring its interactions with other proteins, and studying the consequences of ARNTL2 disruption in various physiological processes and disease states.

Can ARNTL2 expression be influenced by external factors? 01/28/2020

Yes, ARNTL2 expression can be influenced by various external factors, particularly light. Light exposure, especially in the early morning or late evening, can affect the expression of ARNTL2 and other circadian clock genes. Other factors, such as temperature, feeding times, and social cues, can also influence ARNTL2 expression.

What animal models are used to study ARNTL2 function? 12/08/2019

Several animal models, such as mice and zebrafish, have been utilized to study ARNTL2 function. By analyzing genetic modifications in these models, researchers can investigate the effects of ARNTL2 disruption on circadian rhythms, behavior, and other physiological processes.

Are there any genetic variants or mutations associated with ARNTL2? 08/07/2019

While some studies have investigated genetic variations in ARNTL2 and their potential association with sleep disorders or other conditions, the understanding of the specific genetic variants influencing ARNTL2 function or their clinical implications is limited and requires further investigation.

How is ARNTL2 involved in regulating gene expression? 07/25/2019

ARNTL2 binds to specific DNA sequences known as E-boxes, often in conjunction with other proteins like CLOCK or NPAS2. This binding results in the activation or repression of target genes, influencing their transcriptional activity and overall gene expression. By controlling the timing and amplitude of gene expression, ARNTL2 helps regulate circadian rhythms.

Can disruptions in ARNTL2 affect circadian rhythms? 02/26/2018

Research suggests that disruptions in ARNTL2 expression or function can potentially impact circadian rhythms. However, the exact mechanisms and extent of its contribution to circadian regulation are not yet fully understood.

Can ARNTL2 be targeted for therapeutic interventions? 08/19/2017

Targeting ARNTL2 for therapeutic interventions is an area of ongoing research. Understanding its precise role in circadian rhythm regulation and gene expression may provide insights into potential therapies for sleep disorders, metabolic disorders, and other conditions associated with circadian dysregulation. However, further research is necessary to assess the feasibility and effectiveness of such interventions.

Can ARNTL2 mutations affect fertility or reproductive processes? 05/22/2017

The impact of ARNTL2 mutations on fertility and reproductive processes is not currently known. However, given ARNTL2's involvement in circadian regulation and its expression in reproductive tissues, it is possible that mutations in ARNTL2 could affect reproductive processes. Further research is needed to explore this potential link.

Are there any known genetic disorders caused by ARNTL2 mutations? 01/19/2017

Currently, there are no known genetic disorders specifically caused by ARNTL2 mutations. However, variations in ARNTL2 have been implicated in sleep disorders and other circadian-related conditions. It is possible that further research may identify specific genetic disorders associated with ARNTL2 mutations.

Are there any pharmacological agents or natural compounds that can modulate ARNTL2 activity? 12/04/2016

As of now, there are no known pharmacological agents or natural compounds specifically targeting ARNTL2 activity. However, various compounds and interventions that affect the overall circadian clock and gene expression could indirectly influence ARNTL2 function. For example, light therapy, melatonin supplements, and certain medications used to treat sleep disorders can help regulate the circadian rhythm, which could impact ARNTL2 activity. Further research is needed to identify specific compounds that directly modulate ARNTL2 function.

Does ARNTL2 have any interactions with other proteins? 10/19/2016

Yes, ARNTL2 can interact with various proteins to form heterodimers or complexes that regulate gene expression. It forms heterodimers with CLOCK or NPAS2 to bind to DNA and activate target gene transcription. Additionally, ARNTL2 may interact with other proteins involved in circadian clock regulation, such as PER and CRY proteins, to modulate circadian rhythms.

Are there any known diseases or disorders associated with ARNTL2 mutations? 02/05/2016

The specific role of ARNTL2 mutations in disease development is not well-established. However, studies have suggested potential links between ARNTL2 variants and sleep disorders, such as delayed sleep phase syndrome and insomnia. Further research is needed to fully understand the implications of ARNTL2 mutations in disease pathology.

Customer Reviews (6)

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Reviews
02/18/2023

    Its consistent performance and reproducibility have been praised by scientists who have employed it in their studies, with many reporting outstanding results and a high level of satisfaction.

    07/30/2020

      This aspect is crucial in maintaining the scientific rigor of my studies and strengthens the validity of my research findings.

      06/11/2018

        Its exceptional characteristics, coupled with the manufacturer's commitment to customer satisfaction, ensure that I can pursue my scientific investigations with confidence and success.

        05/29/2018

          This strong track record of excellence further attests to the ARNTL2 protein's capability to meet the rigorous demands of research projects.

          08/08/2017

            Its high purity and integrity ensure reliable and reproducible results, minimizing any potential variability in my experimental outcomes.

            08/01/2016

              the ARNTL2 protein offers exceptional quality.

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