Recombinant Human GDF15 GDF15-268H

Recombinant Human GDF15

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Recombinant Human GDF15

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Cat.No. : GDF15-268H
Product Overview : GDF15 Human Recombinant produced in E.Coli is a homodimeric, non-glycosylated, Polypeptide chain containing 2x113 amino acids and having a molecular mass of 24.5 kDa. The GDF15 is purified by proprietary chromatographic techniques.
Description : Bone morphogenetic proteins (e.g., BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.
Source : E.Coli
Species : Human
Form : Sterile Filtered White lyophilized (freeze-dried) powder. GDF15 is lyophilized without additives.
Bio-activity : The biological activity was assessed by the inhibition of DU-145 cells and was found to be 1-2μg/ml.
Molecular Mass : 24.5 kDa
AA Sequence : MARNGDHCPL GPGRCCRLHT VRASLEDLGW ADWVLSPREV QVTMCIGACP SQFRAANMHA QIKTSLHRLK PDTVPAPCCV PASYNPMVLI QKTDTGVSLQ TYDDLLAKDC HCI.
Purity : Greater than 95.0% as determined by RP-HPLC and SDS-PAGE.
Stability : Lyophilized GDF15 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GDF15 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Reconstitution : It is recommended to reconstitute the lyophilized GDF15 in sterile 5mM AcOH (acetic Acid) at a concentration of 100µg/ml, which can then be further diluted to other aqueous solutions.
Gene Name : GDF15 growth differentiation factor 15 [ Homo sapiens (human) ]
Official Symbol : GDF15
Synonyms : GDF15; growth differentiation factor 15; PDF; MIC1; PLAB; MIC-1;NAG-1; PTGFB; GDF-15; PTGF-beta; prostate differentiation factor; NSAID(nonsteroidal anti-inflammatory drug)-activatedprotein 1; NRG-1; Macrophage inhibitory cytokine 1; NSAID-activated gene1 protein; NSAID-regulated gene 1 protein; Placental TGF-beta; Placentalbone morphogeneticprotein; Growth/differentiation factor 15
Gene ID : 9518
mRNA Refseq : NM_004864
Protein Refseq : NP_004855
MIM : 605312
UniProt ID : Q99988
Chromosome Location : 19p13.11
Pathway : Direct p53 effectors
Function : cytokine activity; growth factor activity; transforming growth factor beta receptor binding

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