Active Recombinant Human GDF15
Cat.No. : | GDF15-268H |
Product Overview : | GDF15 Human Recombinant produced in E.Coli is a homodimeric, non-glycosylated, Polypeptide chain containing 2x113 amino acids and having a molecular mass of 24.5 kDa. The GDF15 is purified by proprietary chromatographic techniques. |
- Specification
- Gene Information
- Related Products
Description : | Bone morphogenetic proteins (e.g., BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein. |
Source : | E.Coli |
Species : | Human |
Form : | Sterile Filtered White lyophilized (freeze-dried) powder. GDF15 is lyophilized without additives. |
Bio-activity : | The biological activity was assessed by the inhibition of DU-145 cells and was found to be 1-2μg/ml. |
Molecular Mass : | 24.5 kDa |
AA Sequence : | MARNGDHCPL GPGRCCRLHT VRASLEDLGW ADWVLSPREV QVTMCIGACP SQFRAANMHA QIKTSLHRLK PDTVPAPCCV PASYNPMVLI QKTDTGVSLQ TYDDLLAKDC HCI. |
Purity : | Greater than 95.0% as determined by RP-HPLC and SDS-PAGE. |
Stability : | Lyophilized GDF15 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GDF15 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
Reconstitution : | It is recommended to reconstitute the lyophilized GDF15 in sterile 5mM AcOH (acetic Acid) at a concentration of 100µg/ml, which can then be further diluted to other aqueous solutions. |
Gene Name : | GDF15 growth differentiation factor 15 [ Homo sapiens (human) ] |
Official Symbol : | GDF15 |
Synonyms : | GDF15; growth differentiation factor 15; PDF; MIC1; PLAB; MIC-1;NAG-1; PTGFB; GDF-15; PTGF-beta; prostate differentiation factor; NSAID(nonsteroidal anti-inflammatory drug)-activatedprotein 1; NRG-1; Macrophage inhibitory cytokine 1; NSAID-activated gene1 protein; NSAID-regulated gene 1 protein; Placental TGF-beta; Placentalbone morphogeneticprotein; Growth/differentiation factor 15 |
Gene ID : | 9518 |
mRNA Refseq : | NM_004864 |
Protein Refseq : | NP_004855 |
MIM : | 605312 |
UniProt ID : | Q99988 |
Chromosome Location : | 19p13.11 |
Pathway : | Direct p53 effectors |
Function : | cytokine activity; growth factor activity; transforming growth factor beta receptor binding |
Products Types
◆ Recombinant Protein | ||
GDF15-047H | Recombinant Human GDF15 Protein | +Inquiry |
GDF15-2158R | Recombinant Rat GDF15 Protein, His (Fc)-Avi-tagged | +Inquiry |
GDF15-105H | Recombinant Human GDF15 Protein | +Inquiry |
GDF15-0067H | Recombinant Human GDF15 Protein | +Inquiry |
GDF15-338H | Recombinant Human GDF15 Protein, His tagged | +Inquiry |
◆ Native Protein | ||
GDF15-27680TH | Active Native Human GDF15 Protein | +Inquiry |
◆ Lysates | ||
GDF15-2705HCL | Recombinant Human GDF15 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionGDF15 influences cardiovascular health, impacting heart failure progression and atherosclerotic processes.
GDF15 modulates inflammatory and immune responses, crucial in the context of chronic diseases.
GDF15 contributes to tissue repair and fibrosis, particularly in liver and kidney pathologies.
GDF15 affects cancer development by altering the tumor microenvironment and influencing tumor cell behavior.
Changes in GDF15 expression are linked to aging and age-related diseases, affecting various physiological processes.
GDF15 is involved in regulating energy metabolism and appetite, playing a key role in obesity and metabolic syndromes.
GDF15 is involved in cellular stress responses, influencing apoptosis and cell survival mechanisms.
Customer Reviews (3)
Write a reviewDependable protein purification, consistent and cost-effective.
Precise mass spectrometry analysis, key for proteomics research.
Great antibody validation, enhances our immunoprecipitation experiments.
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