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Active Recombinant Human GDF15

Cat.No. : GDF15-268H
Product Overview : GDF15 Human Recombinant produced in E.Coli is a homodimeric, non-glycosylated, Polypeptide chain containing 2x113 amino acids and having a molecular mass of 24.5 kDa. The GDF15 is purified by proprietary chromatographic techniques.
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Description : Bone morphogenetic proteins (e.g., BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.
Source : E.Coli
Species : Human
Form : Sterile Filtered White lyophilized (freeze-dried) powder. GDF15 is lyophilized without additives.
Bio-activity : The biological activity was assessed by the inhibition of DU-145 cells and was found to be 1-2μg/ml.
Molecular Mass : 24.5 kDa
AA Sequence : MARNGDHCPL GPGRCCRLHT VRASLEDLGW ADWVLSPREV QVTMCIGACP SQFRAANMHA QIKTSLHRLK PDTVPAPCCV PASYNPMVLI QKTDTGVSLQ TYDDLLAKDC HCI.
Purity : Greater than 95.0% as determined by RP-HPLC and SDS-PAGE.
Stability : Lyophilized GDF15 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GDF15 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Reconstitution : It is recommended to reconstitute the lyophilized GDF15 in sterile 5mM AcOH (acetic Acid) at a concentration of 100µg/ml, which can then be further diluted to other aqueous solutions.
Gene Name : GDF15 growth differentiation factor 15 [ Homo sapiens (human) ]
Official Symbol : GDF15
Synonyms : GDF15; growth differentiation factor 15; PDF; MIC1; PLAB; MIC-1;NAG-1; PTGFB; GDF-15; PTGF-beta; prostate differentiation factor; NSAID(nonsteroidal anti-inflammatory drug)-activatedprotein 1; NRG-1; Macrophage inhibitory cytokine 1; NSAID-activated gene1 protein; NSAID-regulated gene 1 protein; Placental TGF-beta; Placentalbone morphogeneticprotein; Growth/differentiation factor 15
Gene ID : 9518
mRNA Refseq : NM_004864
Protein Refseq : NP_004855
MIM : 605312
UniProt ID : Q99988
Chromosome Location : 19p13.11
Pathway : Direct p53 effectors
Function : cytokine activity; growth factor activity; transforming growth factor beta receptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does GDF15 play in cardiovascular diseases, particularly in heart failure and atherosclerosis? 08/14/2022

GDF15 influences cardiovascular health, impacting heart failure progression and atherosclerotic processes.

How does GDF15 influence inflammatory processes and immune responses in chronic diseases? 07/17/2022

GDF15 modulates inflammatory and immune responses, crucial in the context of chronic diseases.

How does GDF15 contribute to tissue repair and fibrosis in organs like the liver and kidneys? 10/16/2021

GDF15 contributes to tissue repair and fibrosis, particularly in liver and kidney pathologies.

What is the impact of GDF15 on cancer development and progression, especially in terms of tumor microenvironment modulation? 05/18/2021

GDF15 affects cancer development by altering the tumor microenvironment and influencing tumor cell behavior.

How do alterations in GDF15 expression impact aging and age-related pathologies? 07/14/2018

Changes in GDF15 expression are linked to aging and age-related diseases, affecting various physiological processes.

How does GDF15 regulate energy metabolism and appetite in the context of obesity and metabolic disorders? 04/21/2018

GDF15 is involved in regulating energy metabolism and appetite, playing a key role in obesity and metabolic syndromes.

What are the mechanisms by which GDF15 affects cellular stress responses and apoptosis? 03/05/2018

GDF15 is involved in cellular stress responses, influencing apoptosis and cell survival mechanisms.

Customer Reviews (3)

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Reviews
03/19/2021

    Dependable protein purification, consistent and cost-effective.

    07/29/2019

      Precise mass spectrometry analysis, key for proteomics research.

      02/22/2019

        Great antibody validation, enhances our immunoprecipitation experiments.

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