Recombinant Human SMAD Family Member 2, His-tagged SMAD2-392H

Recombinant Human SMAD Family Member 2, His-tagged

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Recombinant Human SMAD Family Member 2, His-tagged

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Cat. No. : SMAD2-392H
Product Overview : Recombinant SMAD2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques, 54.4 kDa (487aa).
Description : SMAD2(Mothers against decapentaplegic homolog 2) belongs to the SMAD family of proteins that mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. Phosphorylated Smad2 is then able to form a complex with Smad4 or SARA. These complexes accumulate in the cell nucleus, where they are directly participating in the regulation of gene expression.
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSH MSSILPFTPP VVKRLLGWKK SAGGSGGAGG GEQNGQEEKW CEKAVKSLVK KLKKTGRLDE LEKAITTQNC NTKCVTIPST CSEIWGLSTP NTIDQWDTTG LYSFSEQTRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH HELKAIENCE YAFNLKKDEV CVNPYHYQRV ETPVLPPVLV PRHTEILTEL PPLDDYTHSI PENTNFPAGI EPQSNYIPET PPPGYISEDG ETSDQQLNQS MDTGSPAELS PTTLSPVNHS LDLQPVTYSE PAFWCSIAYY ELNQRVGETF HASQPSLTVD GFTDPSNSER FCLGLLSNVN RNATVEMTRR HIGRGVRLYY IGGEVFAECL SDSAIFVQSP NCNQRYGWHP ATVCKIPPGC NLKIFNNQEF AALLAQSVNQ GFEAVYQLTR MCTIRMSFVK GWGAEYRRQT VTSTPCWIEL HLNGPLQWLD KVLTQMGSPS VRCSSMS
Formulation : Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 100 mM NaCl
Purity : > 95% by SDS - PAGE
Concentration : 0.5 mg/ml (determined by Bradford assay)
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
PDB rendering based on 1dev :

Gene Name : SMAD family member 2 [ Homo sapiens ]
Synonyms : SMAD2; SMAD family member 2; JV18; MADH2; MADR2; JV18-1; hMAD-2; hSMAD2; MGC22139; MGC34440; Sma- and Mad-related protein 2; Mad protein homolog; Mad-related protein 2; mother against DPP homolog 2; SMAD, mothers against DPP homolog 2; MAD, mothers against decapentaplegic homolog 2
Gene ID : 4087
mRNA Refseq : NM_001003652
Protein Refseq : NP_001003652
MIM : 601366
UniProt ID : Q15796
Chromosome Location : 18q21.1
Pathway : Adherens junction; Cell cycle; Colorectal cancer; Pancreatic cancer; TGF-beta signaling pathway; Wnt signaling pathway; Signaling by TGF beta
Function : R-SMAD binding; co-SMAD binding; double-stranded DNA binding; promoter binding; transcription activator activity; transcription factor activity; transcription factor binding; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity; type I transforming growth factor beta receptor binding; ubiquitin protein ligase binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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