"ITGB3" Related Products

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Native Human GPIIbIIIa

Cat.No.: ITGB3-11H
Product Overview: Platelet membrane glycoproteins IIb and IIIa (GPIIb and GPIIIa) constitute the fibrinogen receptor and are required for platelet aggregation. Glycoprotein IIb consists of 2 disulfide-linked subunits GPIIb (MW = 125,000) and GPII (MW= 23,000) while GPIIIa has only one polypeptide chain (MW= 108,000). GPIIbIIIa migrates on gels as follows: GPIIb 136,000 non-reduced and 125,000 reduced. GPIIIa is 97,000 non-reduced and 108,000 reduced. Protein concentration is determined via the Bradford method.
Source: Human plasma
Species: Human
Form: liquid
Purity: >95% by SDS-PAGE analysis
Usage: For in vitro laboratory use only
Notes: Optimal experimental conditions and working dilutions must be determined by the end user. Sample concentration and volume are for example purposes only and do not necessarily represent the product that will be received. Please contact us for a current lot-specific product datasheet.
Storage: -20°C
Concentration: 2.0 mg/ml
Storage Buffer: 0.02M Tris-HCl; 0.1M NaCl; 0.1% Triton X-100; 0.001M CaCl2; 0.05% NaN3; 50% glycerol; pH 7.4
Preservative: SodiumAzide
Shipping: Cold pack
Gene Name: ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) [ Homo sapiens ]
Official Symbol: ITGB3
Synonyms: ITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); GP3A; integrin beta-3; CD61; GPIIIa; platelet glycoprotein IIIa; platelet membrane glycoprotein IIIa; GT; BDPLT2;
Gene ID: 3690
mRNA Refseq: NM_000212
Protein Refseq: NP_000203
UniProt ID: P05106
Chromosome Location: 17q21.32
Pathway: Arf6 signaling events, organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Axon guidance, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Dilated cardiomyopathy, organism-specific biosystem;
Function: cell adhesion molecule binding; identical protein binding; integrin binding; platelet-derived growth factor receptor binding; protein binding; protein disulfide isomerase activity; receptor activity; vascular endothelial growth factor receptor 2 binding; vascular endothelial growth factor receptor 2 binding;

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