Active Recombinant Human TWEAK, FLAG-tagged
| Cat.No. : | TNFSF12-70H |
| Product Overview : | Produced in E. coli. The extracellular domain of human TWEAK (aa 106-249) is fused at the N-terminus to a linker peptide (11 aa) and a FLAG®-tag. |
- Specification
- Gene Information
- Related Products
| Source : | E. coli |
| Species : | Human |
| Tag : | FLAG |
| Form : | Lyophilized. Contains PBS. |
| Bio-activity : | Kills TWEAK sensitive cells. Has a pro-apoptotic effect on several target cell lines and induces angiogenesis and proliferation in endothelial cells. Binds to human and mouse Fn14(TWEAKR). |
| Molecular Mass : | ~18-20 kDa as determined by SDS-PAGE. |
| Purity : | >95% as determined by SDS-PAGE. Endotoxin:<0.1 eu/μg of purified protein (lal>test). |
| Usage : | For in vitro research use only. Not for use in diagnostics or in humans. |
| Storage : | Store lyophilized protein at at -20°C. After reconstitution, aliquot and store at -20°C. |
| Reconstitution : | Reconstitute in 100 μL sterile water for a 0.1 mg/mL solution. Further dilutions should be made with medium containing 5% fetal calf serum. |
| Warning : | No warranties, expressed or implied, are made regarding the use of this product. Creative Biomart is not liable for any damage, personal injury, or economic loss caused by this product. |
| Gene Name : | TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 [ Homo sapiens ] |
| Official Symbol : | TNFSF12 |
| Synonyms : | TNFSF12; tumor necrosis factor (ligand) superfamily, member 12; tumor necrosis factor ligand superfamily member 12; APO3L; DR3LG; TWEAK; APO3 ligand; APO3/DR3 ligand; TNF-related WEAK inducer of apoptosis; MGC20669; MGC129581; |
| Gene ID : | 8742 |
| mRNA Refseq : | NM_003809 |
| Protein Refseq : | NP_003800 |
| MIM : | 602695 |
| UniProt ID : | O43508 |
| Chromosome Location : | 17p13.1 |
| Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Gene Expression, organism-specific biosystem; Regulation of mRNA Stability by Proteins that Bind AU-rich Elements, organism-specific biosystem; Stabilization of mRNA by HuR, organism-specific biosystem; |
| Function : | cytokine activity; cytokine activity; protein binding; receptor binding; tumor necrosis factor receptor binding; |
Products Types
| ◆ Lysates | ||
| TNFSF12-1204RCL | Recombinant Rat TNFSF12 cell lysate | +Inquiry |
| TNFSF12-1155CCL | Recombinant Cynomolgus TNFSF12 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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