Recombinant Human SNAI2, His-tagged

• Cat.No.: SNAI2-58H
• Product Overview: Recombinant human SNAI2, fused to His-tag at N-terminus, was expressed in E.coli.

Specification

• Description: SNAI2 also known as Zinc finger protein SNAI2. This protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. SNAI2 is involved in epithelial-mesenchymal transitions and has antiapoptotic activity.
• Source: E.coli
• Species: Human
• Tag: His
• Form: Liquid, In 20mM Tris-HCl Buffer (pH8.0) containing 10% glycerol
• Molecular Mass: 32.4kDa (291aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMPRSFLV KKHFNASKKP NYSELDTHTV IISPYLYESY SMPVIPQPEI LSSGAYSPIT VWTTAAPFHA QLPNGLSPLS GYSSSLGRVS PPPPSDTSSK DHSGSESPIS DEEERLQSKL SDPHAIEAEK FQCNLCNKTY STFSGLAKHK QLHCDAQSRK SFSCKYCDKE YVSLGALKMH IRTHTLPCVC KICGKAFSRP WLLQGHIRTH TGEKPFSCPH CNRAFADRSN LRAHLQTHSD VKKYQCKNCS KTFSRMSLLH KHEESGCCVA H
• Purity: >80% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: SNAI2 snail homolog 2 (Drosophila) [ Homo sapiens ]
• Official Symbol: SNAI2
• Synonyms: SNAI2; snail homolog 2 (Drosophila); SLUG, slug homolog, zinc finger protein (chicken); zinc finger protein SNAI2; SLUGH1; SNAIL2; protein snail homolog 2; neural crest transcription factor SLUG; slug (chicken homolog), zinc finger protein; SLUG; WS2D; MGC10182
• Gene ID: 6591
• mRNA Refseq: NM_003068
• Protein Refseq: NP_003059
• MIM: 602150
• UniProt ID: O43623
• Chromosome Location: 8q11.21
• Pathway: Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Direct p53 effectors, organism-specific biosystem; Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem; Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem
• Function: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; chromatin binding; metal ion binding; sequence-specific DNA binding; sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; zinc ion binding