"NOTCH1" Related Products

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Recombinant Human NOTCH1 protein, Fc-tagged

Cat.No. : NOTCH1-384H
Product Overview : Recombinant Human NOTCH1(Ala19 - Gln526) fused with Fc of Human IgG1 at C-terminal was expressed in NS0.
Source : NS0
Species : Human
Tag : Fc
Predicted N Terminal : Ala19
Form : Lyophilized from a 0.2 μm filtered solution in PBS.
Bio-activity : Measured by its binding ability in a functional ELISA. Immobilized rhNotch-1 Fc Chimera at 5 µg/mL (100 µL/well) can bind rrJagged-1/Fc Chimera with an apparent KD <5 nM in a functional ELISA.
Molecular Mass : Predicted Molecular Mass: 80.1 (monomer) kDa;SDS-PAGE: 115-125 kDa, reducing conditions.
Endotoxin : <1.0 EU per 1 μg of the protein by the LAL method.
Purity : >90%, by SDS-PAGE under reducing conditions and visualized by silver stain
Storage : Avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 centigrade as supplied.1 month, 2 to 8 centigrade under sterile conditions after reconstitution.3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution : Reconstitute at 100 μg/mL in sterile PBS.
Gene Name : NOTCH1 notch 1 [ Homo sapiens ]
Official Symbol : NOTCH1
Synonyms : NOTCH1; notch 1; Notch (Drosophila) homolog 1 (translocation associated) , Notch homolog 1, translocation associated (Drosophila) , TAN1; neurogenic locus notch homolog protein 1; Notch homolog 1, translocation-associated; translocation-associated notch protein TAN-1; hN1; TAN1;
Gene ID : 4851
mRNA Refseq : NM_017617
Protein Refseq : NP_060087
MIM : 190198
UniProt ID : P46531
Chromosome Location : 9q34.3
Pathway : Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Dorso-ventral axis formation, organism-specific biosystem; Dorso-ventral axis formation, conserved biosystem
Function : calcium ion binding; chromatin DNA binding; core promoter binding; protein binding; receptor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;

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