Recombinant Human MDM2, GST-tagged MDM2-2320H

Recombinant Human MDM2, GST-tagged

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Recombinant Human MDM2, GST-tagged

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Cat.No. : MDM2-2320H
Product Overview : Recombinant Human MDM2, fused with an N-terminal GST (glutathione S-transferase) tag, was expressed in E. coli.
Description : This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
Source : E. coli
Species : Human
Tag : GST
Form : 50 mM Hepes pH 8, 200 mM NaCl, 10% glycerol, 5 mM TCEP
Bio-activity : Recombinant Human GST-Mdm2 is a Ubiquitin ligase (E3) that functions downstream of a Ubiquitin-activating (E1) enzyme and a Ubiquitin-conjugating (E2) enzyme to conjugate Ubiquitin to substrate proteins. Reaction conditions will need to be optimized for each specific application. We recommend an initial Recombinant Human GST-Mdm2 concentration of 0.5-4 µM.
Molecular Mass : 82 kDa
Purity : >85%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain.
Storage : Avoid repeated freeze-thaw cycles.12 months from date of receipt, -70 ºC as supplied.3 months, -70 ºC under sterile conditions after opening.
Gene Name : MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase [ Homo sapiens (human) ]
Official Symbol : MDM2
Synonyms : MDM2; MDM2 proto-oncogene, E3 ubiquitin protein ligase; HDMX; hdm2; ACTFS; E3 ubiquitin-protein ligase Mdm2; MDM2 oncogene, E3 ubiquitin protein ligase; Mdm2, p53 E3 ubiquitin protein ligase homolog; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; double minute 2, human homolog of; p53-binding protein; oncoprotein Mdm2
Gene ID : 4193
mRNA Refseq : NM_001145337
Protein Refseq : NP_001138809
MIM : 164785
UniProt ID : Q00987
Chromosome Location : 12q14.3-q15
Pathway : AKT phosphorylates targets in the cytosol; Adaptive Immune System; Cellular Senescence
Function : enzyme binding; identical protein binding; ligase activity; p53 binding

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