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Recombinant Human STAT5a, His-tagged

Cat.No. : STAT5A-01H
Product Overview : A DNA sequence encoding Human STAT5A ( a.a.129-712 ) was fused with a His tag .
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Source : E.coli
Species : Human
Tag : His
Form : 20 mM Tris-HCl, 200 mM NaCl, pH7.4
Molecular Mass : ~67kDa
AA Sequence : PAGILVDAMSQKHLQINQTFEELRL VTQDTENELKKLQQTQEYFIIQYQE SLRIQAQFAQLAQLSPQERLSRETA LQQKQVSLEAWLQREAQTLQQYRVE LAEKHQKTLQLLRKQQTIILDDELI QWKRRQQLAGNGGPPEGSLDVLQSW CEKLAEIIWQNRQQIRRAEHLCQQL PIPGPVEEMLAEVNATITDIISALV TSTFIIEKQPPQVLKTQTKFAATVR LLVGGKLNVHMNPPQVKATIISEQQ AKSLLKNENTRNECSGEILNNCCVM EYHQATGTLSAHFRNMSLKRIKRAD RRGAESVTEEKFTVLFESQFSVGSN ELVFQVKTLSLPVVVIVHGSQDHNA TATVLWDNAFAEPGRVPFAVPDKVL WPQLCEALNMKFKAEVQSNRGLTKE NLVFLAQKLFNNSSSHLEDYSGLSV SWSQFNRENLPGWNYTFWQWFDGVM EVLKKHHKPHWNDGAILGFVNKQQA HDLLINKPDGTFLLRFSDSEIGGIT IAWKFDSPERNLWNLKPFTTRDFSI RSLADRLGDLSYLIYVFPDRPKDEV FSKYYTPVLAKAVDGYVKPQIKQVV PEFVNASAD
Purity : >92% as determined by SDS-PAGE
Storage : Short Term Storage +4°C. Long Term Storage -20°C. Prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Gene Name : STAT5A signal transducer and activator of transcription 5A [ Homo sapiens ]
Official Symbol : STAT5A
Synonyms : STAT5A; signal transducer and activator of transcription 5A; STAT5; MGF;
Gene ID : 6776
mRNA Refseq : NM_003152
Protein Refseq : NP_003143
MIM : 601511
UniProt ID : P42229
Chromosome Location : 17q11.2
Pathway : Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adipogenesis, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; CD40/CD40L signaling, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Chronic myeloid leukemia, organism-specific biosystem;
Function : RNA polymerase II core promoter sequence-specific DNA binding; calcium ion binding; double-stranded DNA binding; protein binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; signal transducer activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does STAT5A contribute to immune system regulation? 01/28/2022

STAT5A plays a crucial role in regulating immune responses by influencing the differentiation and function of immune cells such as T cells and natural killer cells.

Are there any ongoing clinical trials targeting STAT5A? 12/01/2020

Yes, several clinical trials are exploring the therapeutic potential of targeting STAT5A in different cancer types.

What challenges are associated with targeting STAT5A in clinical applications? 07/17/2019

One challenge is the need for specificity in targeting STAT5A to avoid adverse effects on normal cellular functions.

Can STAT5A be a prognostic marker in cancer patients? 01/05/2018

Elevated levels of activated STAT5A have been correlated with poor prognosis in certain cancers, suggesting its potential as a prognostic marker.

In which diseases are dysregulations of STAT5A associated? 12/25/2017

Dysregulations of STAT5A have been linked to leukemia, breast cancer, and prostate cancer, among other diseases.

Customer Reviews (3)

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Reviews
10/17/2022

    The manufacturer offers exceptional technical assistance, guiding researchers through various stages of their experiments.

    10/04/2016

      Its reliable bioactivity makes it an ideal choice for a diverse range of experimental applications.

      05/29/2016

        By providing comprehensive data and resources, the manufacturer enables researchers to design and implement their trials with confidence, ensuring the desired outcomes.

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