Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human FZD8, Fc-tagged therapeutic protein

Cat.No. : FZD8-P012H
Product Overview : Recombinant Human FZD8, HIgG1 Fc-tagged therapeutic protein is a fusion protein that consists of a portion of the Frizzled 8 receptor from the Wnt pathway fused to the Fc domain of a human IgG1. It selectively binds Wnt ligands that are activators of Wnt signaling. FZD8-Fc has shown potent anti-cancer stem cell effects and induces tumor cell differentiation in preclinical studies.
  • Specification
  • Gene Information
  • Related Products
Description : This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.
Species : Human
Tag : Fc
Endotoxin : < 1.0 EU per μg of the protein
Purity : >95%
Gene Name : FZD8 frizzled family receptor 8 [ Homo sapiens ]
Official Symbol : FZD8
Synonyms : FZD8; frizzled family receptor 8; frizzled (Drosophila) homolog 8 , frizzled 8, seven transmembrane spanning receptor , frizzled homolog 8 (Drosophila); frizzled-8; frizzled homolog 8; frizzled 8, seven transmembrane spanning receptor; FZ-8; hFZ8;
Gene ID : 8325
mRNA Refseq : NM_031866
Protein Refseq : NP_114072
MIM : 606146
UniProt ID : Q9H461
Chromosome Location : 10p11.2
Pathway : Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Class B/2 (Secretin family receptors), organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Melanogenesis, organism-specific biosystem;
Function : G-protein coupled receptor activity; PDZ domain binding; Wnt-activated receptor activity; Wnt-activated receptor activity; Wnt-protein binding; receptor activity; receptor binding; signal transducer activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All FZD8 Products

Required fields are marked with *

My Review for All FZD8 Products

Required fields are marked with *

0

Inquiry Basket

cartIcon
logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends