Recombinant Human FZD8, Fc-tagged therapeutic protein FZD8-P012H

Recombinant Human FZD8, Fc-tagged therapeutic protein

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Recombinant Human FZD8, Fc-tagged therapeutic protein

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Cat.No. : FZD8-P012H
Product Overview : Recombinant Human FZD8, HIgG1 Fc-tagged therapeutic protein is a fusion protein that consists of a portion of the Frizzled 8 receptor from the Wnt pathway fused to the Fc domain of a human IgG1. It selectively binds Wnt ligands that are activators of Wnt signaling. FZD8-Fc has shown potent anti-cancer stem cell effects and induces tumor cell differentiation in preclinical studies.
Description : This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.
Species : Human
Tag : Fc
Endotoxin : < 1.0 EU per μg of the protein
Purity : >95%
Gene Name : FZD8 frizzled family receptor 8 [ Homo sapiens ]
Official Symbol : FZD8
Synonyms : FZD8; frizzled family receptor 8; frizzled (Drosophila) homolog 8 , frizzled 8, seven transmembrane spanning receptor , frizzled homolog 8 (Drosophila); frizzled-8; frizzled homolog 8; frizzled 8, seven transmembrane spanning receptor; FZ-8; hFZ8;
Gene ID : 8325
mRNA Refseq : NM_031866
Protein Refseq : NP_114072
MIM : 606146
UniProt ID : Q9H461
Chromosome Location : 10p11.2
Pathway : Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Class B/2 (Secretin family receptors), organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Melanogenesis, organism-specific biosystem;
Function : G-protein coupled receptor activity; PDZ domain binding; Wnt-activated receptor activity; Wnt-activated receptor activity; Wnt-protein binding; receptor activity; receptor binding; signal transducer activity;

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