Recombinant Human FZD8, Fc-tagged therapeutic protein
Cat.No. : | FZD8-P012H |
Product Overview : | Recombinant Human FZD8, HIgG1 Fc-tagged therapeutic protein is a fusion protein that consists of a portion of the Frizzled 8 receptor from the Wnt pathway fused to the Fc domain of a human IgG1. It selectively binds Wnt ligands that are activators of Wnt signaling. FZD8-Fc has shown potent anti-cancer stem cell effects and induces tumor cell differentiation in preclinical studies. |
- Specification
- Gene Information
- Related Products
Description : | This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. |
Species : | Human |
Tag : | Fc |
Endotoxin : | < 1.0 EU per μg of the protein |
Purity : | >95% |
Gene Name : | FZD8 frizzled family receptor 8 [ Homo sapiens ] |
Official Symbol : | FZD8 |
Synonyms : | FZD8; frizzled family receptor 8; frizzled (Drosophila) homolog 8 , frizzled 8, seven transmembrane spanning receptor , frizzled homolog 8 (Drosophila); frizzled-8; frizzled homolog 8; frizzled 8, seven transmembrane spanning receptor; FZ-8; hFZ8; |
Gene ID : | 8325 |
mRNA Refseq : | NM_031866 |
Protein Refseq : | NP_114072 |
MIM : | 606146 |
UniProt ID : | Q9H461 |
Chromosome Location : | 10p11.2 |
Pathway : | Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Class B/2 (Secretin family receptors), organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Melanogenesis, organism-specific biosystem; |
Function : | G-protein coupled receptor activity; PDZ domain binding; Wnt-activated receptor activity; Wnt-activated receptor activity; Wnt-protein binding; receptor activity; receptor binding; signal transducer activity; |
Products Types
◆ Recombinant Protein | ||
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FZD8-2088R | Recombinant Rat FZD8 Protein, His (Fc)-Avi-tagged | +Inquiry |
FZD8-946HB | Recombinant Human FZD8 protein, His-Avi-tagged, Biotinylated | +Inquiry |
FZD8-6122M | Recombinant Mouse FZD8 Protein | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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