Active Recombinant Human TGFBR3

• Cat.No.: TGFBR3-193H
• Product Overview: Recombinant Human TGFBR3 (Accession # AAA67061.1) Gly21-Asp781 was produced in Mouse myeloma cell line, NS0-derived.

Specification

• Source: Mammalian cells
• Species: Human
• Predicted N Terminal: Gly21
• Form: Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
• Bio-activity: Measured by its ability to inhibit TGF-beta 2 activity on HT-2 mouse T cells. Tsang, M. et al. (1995) Cytokine 7:389.The ED50 for this effect is typically 20 - 50 ng/mL in the presence of 0.4 ng/mL of rhTGF-beta 2.
• Molecular Mass: Recombinant Human TGFBR3 has a calculated MW of 84 kDa. In SDS-PAGE migrates as 100 kDa, reducing conditions.
• Purity: >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Storage: Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).
• Reconstitution: Reconstitute at 200 µg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Gene Information

• Gene Name: TGFBR3 transforming growth factor, beta receptor III [ Homo sapiens ]
• Official Symbol: TGFBR3
• Synonyms: TGFBR3; transforming growth factor, beta receptor III; transforming growth factor, beta receptor III (betaglycan, 300kDa); transforming growth factor beta receptor type 3; betaglycan; betaglycan proteoglycan; BGCAN; TGFR-3; TGF-beta receptor type 3; TGF-beta receptor type III
• Gene ID: 7049
• mRNA Refseq: NM_001195683
• Protein Refseq: NP_001182612
• MIM: 600742
• UniProt ID: Q03167
• Chromosome Location: 1p33-p32

Reviews

05/10/2022

Great product !

02/18/2020

Seamless delivery process—ordered, received, and ready for experiments.

08/31/2018

Timely delivery is key, and this product arrived on schedule.

Q&As

What are the implications of TGFBR3 mutations in the context of hereditary connective tissue disorders?

TGFBR3 mutations are associated with hereditary connective tissue disorders, impacting extracellular matrix homeostasis and contributing to conditions like Loeys-Dietz syndrome.

How does TGFBR3 influence embryonic development, and what are the consequences of its dysregulation during development?

TGFBR3 plays a role in embryonic development, and dysregulation may lead to developmental abnormalities due to disrupted TGF-beta signaling.

Can you explain the role of TGFBR3 in mediating interactions between cells and extracellular matrix components?

TGFBR3 facilitates cell-ECM interactions by modulating TGF-beta signaling, influencing processes like cell adhesion and migration.

How does TGFBR3 contribute to the modulation of TGF-beta signaling pathways?

TGFBR3 acts as a co-receptor, enhancing the binding of TGF-beta ligands to TGF-beta receptors, and modulates downstream signaling events.

What are the functional consequences of TGFBR3 mutations in the context of cardiovascular diseases?

TGFBR3 mutations are implicated in cardiovascular diseases, affecting TGF-beta-mediated processes in vascular smooth muscle cells and cardiac tissues.