Recombinant Human BCL6, His & Trx-tagged


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Recombinant Human BCL6, His & Trx-tagged

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Cat.No. : BCL6-252H
Product Overview : Recombinant Human BCL6(Met 1-Met 150) fussed with His & Trx tag at N-terminal was expressed in E. coli.
Description : The protein encoded by this gene is an evolutionarily conserved 95-kDa protein containing six C-terminal zinc-finger motifs and an N-terminal POZ domain. It has been reported that BCL-6 is present in DNA-binding complexes in nuclear extracts from various B-cell lines. There are many relationships between non-Hodgkin's lymphoma, diffuse large cell lymphoma and BCL6’s translocations. BCL6 can repress transcription from promoters linked to its DNA target sequence and this activity is dependent upon specific DNA-binding and the presence of an intact N-terminal half of the protein.
Source : E. coli
Species : Human
Tag : His & Trx
Predicted N Terminal : Met
Form : Lyophilized from sterile 20mM Tris, 10% glycerol, pH 8.0
Molecular Mass : The recombinant human BCL6/Trx fusion protein consisting of 309 amino acids and has a calculated molecular mass of 34.2 kDa. It migrates as an approximately 33 kDa band in SDS-PAGE under reducing conditions.
Purity : > 92 % as determined by SDS-PAGE
Stability : Samples are stable for up to twelve months from date of receipt at -70 centigrade
Storage : Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name : BCL6 B-cell CLL/lymphoma 6 [ Homo sapiens ]
Official Symbol : BCL6
Synonyms : BCL5; LAZ3; BCL6A; ZNF51; ZBTB27; B-cell lymphoma 6 protein; B-cell lymphoma 5 protein; B-cell lymphoma 6 protein transcript; BCL-5; BCL-6; cys-his2 zinc finger transcription factor; lymphoma-associated zinc finger gene on chromosome 3; protein LAZ-3; zinc finger and BTB domain-containing protein 27; zinc finger protein 51; zinc finger transcription factor BCL6S
Gene ID : 604
mRNA Refseq : NM_001130845
Protein Refseq : NP_001124317
MIM : 109565
UniProt ID : P41182
Chromosome Location : 3q27
Pathway : B Cell Receptor Signaling Pathway, organism-specific biosystem; DNA damage response (only ATM dependent), organism-specific biosystem; FoxO family signaling, organism-specific biosystem
Function : RNA polymerase II regulatory region sequence-specific DNA binding; chromatin DNA binding; metal ion binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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