Recombinant Human ADA protein, His-tagged


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Recombinant Human ADA protein, His-tagged

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Cat.No. : ADA-1112H
Product Overview : Recombinant Human ADA(Met1-Leu363) fused with His tag at C-terminal was expressed in Insect cells.
Description : Adenosine Deaminase (ADA, adenosine aminohydrolase) is one of the key enzymes of purine nucleotide catabolism. It catalyses the hydrolytic deamination of adenosine and deoxy-adenosine to inosine and deoxyinosine. ADA is expressed in virtually all tissues and is expressed at high levels in T-lymphocytes. Adenosine Deaminase deficiency can cause a form of SCID (severe combined immunodeficiency) and lymphopenia in both B- and T-cell lineages. ADA can be used as a sensitive diagnostic marker for tuberculous pleuritis. Although it is primarily a cytosolic enzyme, ADA is known to be a positive regulator of T-cell co-activation due to its binding to CD26 at the cell surface. The interaction of ADA with CD26 regulates lymphocyte-epithelial cell adhesion.
Source : Insect cells
Species : Human
Tag : His
Predicted N Terminal : Met
Form : Supplied as a 0.2 μm filtered solution in Tris, NaCl and Glycerol.
Bio-activity : >44,000 pmol/min/μg
Molecular Mass : Predicted Molecular Mass: 42 kDa;SDS-PAGE: 40-42 kDa, reducing conditions.
Endotoxin : <1.0 EU per 1 μg of the protein by the LAL method.
Purity : >95%, by SDS-PAGE under reducing conditions
Storage : Avoid repeated freeze-thaw cycles.3 months from date of receipt, -70 centigrade as supplied.1 month, -70 centigrade under sterile conditions after opening.
Gene Name : ADA adenosine deaminase [ Homo sapiens ]
Official Symbol : ADA
Synonyms : ADA; adenosine deaminase; adenosine aminohydrolase;
Gene ID : 100
mRNA Refseq : NM_000022
Protein Refseq : NP_000013
MIM : 608958
UniProt ID : P00813
Chromosome Location : 20q13.12
Pathway : C-MYB transcription factor network, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem; Primary immunodeficiency, organism-specific biosystem; Primary immunodeficiency, conserved biosystem; Purine metabolism, organism-specific biosystem;
Function : adenosine deaminase activity; adenosine deaminase activity; hydrolase activity; metal ion binding; protein binding; purine nucleoside binding; zinc ion binding; zinc ion binding;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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