Recombinant Human ADA protein, His-tagged ADA-1112H

Recombinant Human ADA protein, His-tagged

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Recombinant Human ADA protein, His-tagged

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Cat.No. : ADA-1112H
Product Overview : Recombinant Human ADA(Met1-Leu363) fused with His tag at C-terminal was expressed in Insect cells.
Description : Adenosine Deaminase (ADA, adenosine aminohydrolase) is one of the key enzymes of purine nucleotide catabolism. It catalyses the hydrolytic deamination of adenosine and deoxy-adenosine to inosine and deoxyinosine. ADA is expressed in virtually all tissues and is expressed at high levels in T-lymphocytes. Adenosine Deaminase deficiency can cause a form of SCID (severe combined immunodeficiency) and lymphopenia in both B- and T-cell lineages. ADA can be used as a sensitive diagnostic marker for tuberculous pleuritis. Although it is primarily a cytosolic enzyme, ADA is known to be a positive regulator of T-cell co-activation due to its binding to CD26 at the cell surface. The interaction of ADA with CD26 regulates lymphocyte-epithelial cell adhesion.
Source : Insect cells
Species : Human
Tag : His
Predicted N Terminal : Met
Form : Supplied as a 0.2 μm filtered solution in Tris, NaCl and Glycerol.
Bio-activity : >44,000 pmol/min/μg
Molecular Mass : Predicted Molecular Mass: 42 kDa;SDS-PAGE: 40-42 kDa, reducing conditions.
Endotoxin : <1.0 EU per 1 μg of the protein by the LAL method.
Purity : >95%, by SDS-PAGE under reducing conditions
Storage : Avoid repeated freeze-thaw cycles.3 months from date of receipt, -70 centigrade as supplied.1 month, -70 centigrade under sterile conditions after opening.
Gene Name : ADA adenosine deaminase [ Homo sapiens ]
Official Symbol : ADA
Synonyms : ADA; adenosine deaminase; adenosine aminohydrolase;
Gene ID : 100
mRNA Refseq : NM_000022
Protein Refseq : NP_000013
MIM : 608958
UniProt ID : P00813
Chromosome Location : 20q13.12
Pathway : C-MYB transcription factor network, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem; Primary immunodeficiency, organism-specific biosystem; Primary immunodeficiency, conserved biosystem; Purine metabolism, organism-specific biosystem;
Function : adenosine deaminase activity; adenosine deaminase activity; hydrolase activity; metal ion binding; protein binding; purine nucleoside binding; zinc ion binding; zinc ion binding;

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