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Recombinant Human ADA protein, His-tagged

Cat.No.: ADA-1112H
Product Overview: Recombinant Human ADA(Met1-Leu363) fused with His tag at C-terminal was expressed in Insect cells.
Description: Adenosine Deaminase (ADA, adenosine aminohydrolase) is one of the key enzymes of purine nucleotide catabolism. It catalyses the hydrolytic deamination of adenosine and deoxy-adenosine to inosine and deoxyinosine. ADA is expressed in virtually all tissues and is expressed at high levels in T-lymphocytes. Adenosine Deaminase deficiency can cause a form of SCID (severe combined immunodeficiency) and lymphopenia in both B- and T-cell lineages. ADA can be used as a sensitive diagnostic marker for tuberculous pleuritis. Although it is primarily a cytosolic enzyme, ADA is known to be a positive regulator of T-cell co-activation due to its binding to CD26 at the cell surface. The interaction of ADA with CD26 regulates lymphocyte-epithelial cell adhesion.
Source: Insect cells
Species: Human
Tag: His
Predicted N Terminal: Met
Form: Supplied as a 0.2 μm filtered solution in Tris, NaCl and Glycerol.
Bio-activity: >44,000 pmol/min/μg
Molecular Mass: Predicted Molecular Mass: 42 kDa;SDS-PAGE: 40-42 kDa, reducing conditions.
Endotoxin: <1.0 EU per 1 μg of the protein by the LAL method.
Purity: >95%, by SDS-PAGE under reducing conditions
Storage: Avoid repeated freeze-thaw cycles.3 months from date of receipt, -70 centigrade as supplied.1 month, -70 centigrade under sterile conditions after opening.
Gene Name: ADA adenosine deaminase [ Homo sapiens ]
Official Symbol: ADA
Synonyms: ADA; adenosine deaminase; adenosine aminohydrolase;
Gene ID: 100
mRNA Refseq: NM_000022
Protein Refseq: NP_000013
MIM: 608958
UniProt ID: P00813
Chromosome Location: 20q13.12
Pathway: C-MYB transcription factor network, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem; Primary immunodeficiency, organism-specific biosystem; Primary immunodeficiency, conserved biosystem; Purine metabolism, organism-specific biosystem;
Function: adenosine deaminase activity; adenosine deaminase activity; hydrolase activity; metal ion binding; protein binding; purine nucleoside binding; zinc ion binding; zinc ion binding;

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