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Active Recombinant Human BMPR2, Fc-tagged, Biotinylated

Cat.No. : BMPR2-556H
Product Overview : The recombinant human BMPR2-Fc fusion protein is expressed as a 352 amino acid protein consisting of Ser27 - Thr150 region of BMPR2 (UniProt accession #Q13873) and a C-terminal Fc fusion from human IgG1, which exists as a dimer under non-reducing condition.
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Source : Human cells
Species : Human
Tag : Fc
Form : Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule).
Bio-activity : Recombinant BMPR2 protein binds human/mouse BMP2/BMP7/GDF9, and blocks BMP2/BMP7/GDF9-induced signaling activity
Molecular Mass : Calculated molecular mass (kDa): 39.5; Estimated by SDS-PAGE under reducing condition (kDa): ~55
AA Sequence : SQNQERLCAFKDPYQQDLGIGESRI SHENGTILCSKGSTCYGLWEKSKGD INLVKQGCWSHIGDPQECHYEECV VTTTPPSIQNGTYRFCCCSTDLCNV NFTENFPPPDTTPLSPPHSFNRDET STGTHTCPPCPAPELLGGPSVFL FPPKPKDTLMISRTPEVTCVVVDVS HEDPEVKFNWYVDGVEVHNAKTKPR EEQYNSTYRVVSVLTVLHQDWLNG KEYKCKVSNKALPAPIEKTISKAKG QPREPQVYTLPPSREEMTKNQVSLT CLVKGFYPSDIAVEWESNGQPEN NYKTTPPVLDSDGSFFLYSKLTVDK SRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK
Endotoxin : <0.1 eu per 1 μg of purified recombinant protein determined by the
Purity : >95% judged by SDS-PAGE under reducing condition
Storage : The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.
Gene Name : BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) [ Homo sapiens ]
Official Symbol : BMPR2
Synonyms : BMPR2; bone morphogenetic protein receptor, type II (serine/threonine kinase); PPH1, primary pulmonary hypertension 1; bone morphogenetic protein receptor type-2; BMPR II; BMPR3; BRK 3; T ALK; BMPR-2; BMP type-2 receptor; BMP type II receptor; type II activin receptor-like kinase; bone morphogenetic protein receptor type II; type II receptor for bone morphogenetic protein-4; BMR2; PPH1; BRK-3; T-ALK; BMPR-II; FLJ41585; FLJ76945;
Gene ID : 659
mRNA Refseq : NM_001204
Protein Refseq : NP_001195
MIM : 600799
UniProt ID : Q13873
Chromosome Location : 2q33-q34
Pathway : ALK1 signaling events, organism-specific biosystem; ALK2 signaling events, organism-specific biosystem; BMP receptor signaling, organism-specific biosystem; BMP signalling and regulation, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Heart Development, organism-specific biosystem;
Function : ATP binding; activin receptor activity, type II; growth factor binding; metal ion binding; nucleotide binding; protein binding; receptor activity; transforming growth factor beta-activated receptor activity; transmembrane receptor protein serine/threonine kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does BMPR2 play in the development and progression of pulmonary arterial hypertension (PAH)? 02/01/2022

BMPR2 plays a significant role in PAH, influencing vascular cell proliferation and vascular remodeling.

What is the impact of BMPR2 mutations on hereditary hemorrhagic telangiectasia? 11/19/2020

Mutations in BMPR2 contribute to hereditary hemorrhagic telangiectasia, impacting vascular development.

How do alterations in BMPR2 expression or signaling affect embryonic development and congenital anomalies? 05/14/2020

Changes in BMPR2 signaling impact embryonic development, potentially resulting in congenital anomalies.

What are the effects of BMPR2 dysregulation on renal function and kidney disease? 05/05/2020

Dysregulation of BMPR2 affects renal function, potentially leading to kidney disease and dysfunction.

How does BMPR2 mediate the signaling pathways of bone morphogenetic proteins (BMPs) in bone formation and remodeling? 06/01/2019

BMPR2 is key in bone morphogenetic protein signaling, crucial for bone growth and remodeling.

How does BMPR2 influence cardiovascular development and disease, particularly in heart valve formation? 01/20/2019

BMPR2 is involved in cardiovascular development, particularly affecting heart valve formation and function.

How does BMPR2 contribute to the regulation of cell proliferation and apoptosis in various tissues? 04/18/2018

BMPR2 regulates cell proliferation and apoptosis, playing a role in tissue homeostasis.

Customer Reviews (3)

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Reviews
11/20/2022

    High-quality protein crystallography services, exceptional outcomes.

    04/28/2022

      Critical expertise in protein engineering, unmatched service quality.

      07/29/2019

        Swift and reliable protein sequencing, invaluable for our research.

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