||HDAC1 was cloned from human brain cDNA and expressed in insect cells using a baculoviral expression system.Full Length Human HDAC1 – Class I, 59 kD with his tag.
||Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
||HDAC3 was cloned from human brain cDNA and expressed in insect cells using a baculoviral expression system.
||Purified, active enzyme.
||Ni2+ Affinity Column
||1000 units per vial. 1 unit is defined as the amount of enzyme that will convert 1picomole per minute per ug at pH8 at 30°C.
||>6 months from date of shipment
||25mM Tris pH8, 120mM NaCl, 0.05% Tween-20 & 40% Glycerol