Recombinant Human TNFRSF1A, Fc-tagged, Biotinylated TNFRSF1A-707H

Recombinant Human TNFRSF1A, Fc-tagged, Biotinylated

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Recombinant Human TNFRSF1A, Fc-tagged, Biotinylated

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Cat.No. : TNFRSF1A-707H
Product Overview : The recombinant human TNFR1-Fc fusion is expressed as a 416 amino acid protein consisting of Ile22 - Thr211 region of TNFR1 (UniProt accession #P19438) and a C-terminal Fc from human IgG1, which exists as a dimer/tetramer/oligomer under non-reducing conditions.
Source : Human cells
Species : Human
Tag : Fc
Form : Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule).
Bio-activity : Binds to its ligand TNF and inhibits TNF-mediated biological activities including NF-κB activation and cytotoxicity in the mouse L929 fibrosarcoma cells.
Molecular Mass : Calculated molecular mass (kDa): 46.6; Estimated by SDS-PAGE under reducing condition (kDa): 55-60
Endotoxin : <0.1 eu per 1 μg of purified recombinant protein determined by the lal>
Purity : >95% judged by SDS-PAGE under reducing condition.
Storage : The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.
Gene Name : TNFRSF1A tumor necrosis factor receptor superfamily, member 1A [ Homo sapiens ]
Official Symbol : TNFRSF1A
Synonyms : TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A; TNFR1; tumor necrosis factor receptor superfamily member 1A; CD120a; TNF R; TNF R I; TNF R55; TNFAR; TNFR60; TNF-R1; TNF-RI; TNFR-I; tumor necrosis factor-alpha receptor; tumor necrosis factor receptor type 1; tumor necrosis factor binding protein 1; tumor necrosis factor receptor 1A isoform beta; FPF; p55; p60; TBP1; TNF-R; p55-R; TNFR55; TNF-R-I; TNF-R55; MGC19588;
Gene ID : 7132
mRNA Refseq : NM_001065
Protein Refseq : NP_001056
MIM : 191190
UniProt ID : P19438
Chromosome Location : 12p13.2
Pathway : Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; Apoptosis, organism-specific biosystem;
Function : protease binding; protein binding; receptor activity; tumor necrosis factor binding; tumor necrosis factor-activated receptor activity;

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