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Recombinant Human POLA1 protein

Cat.No.: POLA-938H
Product Overview: Recombinant Human POLA1 protein was isolated from HeLa cells.
Description: Human DNA Polymerase Alpha is a replication enzyme used to test the toxicity of drugs on key human replication systems. The simplest DNA Polymerase known in both size and catalysis. Replication enzyme involved in initiation of DNA replication in eukaryotes. A multi-subunit complex, which inhibits DNA polymerase and primase activities.
Source: HeLa
Species: Human
Form: 20 mM Tris-HCl (pH 8.0), 0.25 mM EDTA, 50 mM NaCl, 1 mM β-mercaptoethanol, 0.1% Triton X-100™, 50% (v/v) glycerol
Unit Definition: One unit is the amount of enzyme required to incorporate 1 nmole of total nucleotide into acid-insoluble form in 60 minutes at 37 centigrade.
Applications: 1. Used to test in vitro replication capabilities along with other enzymes.2. Used to test the toxicity of drugs on key human replication systems.3. Used in DNA replication experiments.
Storage: Store at -80 centigrade long term;Store at -20 centigrade short term.
Gene Name: POLA1 polymerase (DNA directed), alpha 1, catalytic subunit [ Homo sapiens ]
Official Symbol: POLA1
Synonyms: POLA1; polymerase (DNA directed), alpha 1, catalytic subunit; POLA, polymerase (DNA directed), alpha , polymerase (DNA directed), alpha 1; DNA polymerase alpha catalytic subunit; p180; DNA polymerase alpha p180 subunit; polymerase (DNA-directed), alpha (70kD); DNA polymerase alpha 1 catalytic subunit; DNA polymerase alpha catalytic subunit p180; POLA; DKFZp686K1672;
Gene ID: 5422
mRNA Refseq: NM_016937
Protein Refseq: NP_058633
MIM: 312040
UniProt ID: P09884
Chromosome Location: Xp22.1-p21.3
Pathway: Activation of the pre-replicative complex, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Chromosome Maintenance, organism-specific biosystem; DNA Replication, organism-specific biosystem; DNA Replication, organism-specific biosystem; DNA Replication Pre-Initiation, organism-specific biosystem;
Function: DNA binding; DNA binding; contributes_to DNA primase activity; DNA-directed DNA polymerase activity; DNA-directed DNA polymerase activity; chromatin binding; double-stranded DNA binding; metal ion binding; nucleoside binding; nucleotide binding; nucleotidyltransferase activity; protein binding; protein heterodimerization activity; purine nucleotide binding; pyrimidine nucleotide binding; transferase activity;

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