||Full Length Human HDAC5–Class IIa, 150kD with GST tag.
||Histone deacetylase 5, also known as HDAC5, is a human gene. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
||HDAC5 was cloned from human brain cDNA and expressed in insect cells using a baculoviral expression system.
||Purified, active enzyme.
||1000 units per vial. 1 unit is defined as the amount of enzyme that will convert 1picomole per minute per ug of protein at pH8 at 30°C.
||>6 months from date of shipment
||25mM Tris pH8, 120mM NaCl, 0.05% Tween-20 & 40% Glycerol.