"HDAC5" Related Products

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Recombinant Human Histone Deacetylase 5, GST-tagged

Cat. No.: HDAC5-396H
Product Overview: Full Length Human HDAC5–Class IIa, 150kD with GST tag.
Description: Histone deacetylase 5, also known as HDAC5, is a human gene. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
Source: HDAC5 was cloned from human brain cDNA and expressed in insect cells using a baculoviral expression system.
Purity: Purified, active enzyme.
Purification Procedure: Glutathione Column
Activity: 1000 units per vial. 1 unit is defined as the amount of enzyme that will convert 1picomole per minute per ug of protein at pH8 at 30°C.
Stability/Shelf-life: >6 months from date of shipment
Buffer Composition: 25mM Tris pH8, 120mM NaCl, 0.05% Tween-20 & 40% Glycerol.
Storage: –80°C
Gene Name: HDAC5 histone deacetylase 5 [ Homo sapiens ]
Synonyms: HDAC5; FLJ90614; HD5; NY-CO-9; HDAC5 histone deacetylase 5; histone deacetylase 5; antigen NY-CO-9; EC 3.5.1.98; KIAA0600; Antigen NY-CO-9.
Gene ID: 10014
mRNA Refseq: NM_001015053
Protein Refseq: NP_001015053
MIM: 605315
UniProt ID: Q9UQL6
Chromosome Location: 17q21
Pathway: Gene Expression
Function: histone deacetylase activity; hydrolase activity; specific transcriptional repressor activity; transcription corepressor activity; transcription factor binding

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