Recombinant Human Histone Deacetylase 5, GST-tagged HDAC5-396H

Recombinant Human Histone Deacetylase 5, GST-tagged

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Recombinant Human Histone Deacetylase 5, GST-tagged

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Cat. No. : HDAC5-396H
Product Overview : Full Length Human HDAC5–Class IIa, 150kD with GST tag.
Description : Histone deacetylase 5, also known as HDAC5, is a human gene. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
Source : HDAC5 was cloned from human brain cDNA and expressed in insect cells using a baculoviral expression system.
Purity : Purified, active enzyme.
Purification Procedure : Glutathione Column
Activity : 1000 units per vial. 1 unit is defined as the amount of enzyme that will convert 1picomole per minute per ug of protein at pH8 at 30°C.
Stability/Shelf-life : >6 months from date of shipment
Buffer Composition : 25mM Tris pH8, 120mM NaCl, 0.05% Tween-20 & 40% Glycerol.
Storage : –80°C
Publication :
Gene Name : HDAC5 histone deacetylase 5 [ Homo sapiens ]
Synonyms : HDAC5; FLJ90614; HD5; NY-CO-9; HDAC5 histone deacetylase 5; histone deacetylase 5; antigen NY-CO-9; EC 3.5.1.98; KIAA0600; Antigen NY-CO-9.
Gene ID : 10014
mRNA Refseq : NM_001015053
Protein Refseq : NP_001015053
MIM : 605315
UniProt ID : Q9UQL6
Chromosome Location : 17q21
Pathway : Gene Expression
Function : histone deacetylase activity; hydrolase activity; specific transcriptional repressor activity; transcription corepressor activity; transcription factor binding

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