Recombinant Mouse Rous Sarcoma Oncogene, SH3 Domain


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Recombinant Mouse Rous Sarcoma Oncogene, SH3 Domain

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Cat. No. : Src-99M
Product Overview : Recombinant Mouse Rous Sarcoma Oncogene protein expressed inE.colicontains SH3 domain and has a molecular mass of 33 kDa.
Description : V-src Sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian).A function for Src tyrosine kinases in normal cell growth was first demonstrated with the binding of family member p56lck to the cytoplasmic tail of the CD4 and CD8 co-receptors on T-cells. Src tyrosine kinases also transmit integrin-dependent signals central to cell movement and proliferation. Hallmarks of v-src induced transformation are rounding of the cell and the formation of actin rich podosomes on the basal surface of the cell. These structures are correlated with increased invasiveness, a process thought to be essential for metastasis.
Source : Recombinant Mouse Src SH3 domain protein expressed inE.coli.
Formulation : Recombinant Mouse Src SH3 domain protein at 100µg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
Application And Suggested Dilutions : •ELISA •Inhibition Assays •Western Blotting.
Characterization : On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 33 kDa.
Other Ariants Available : UD DOMAIN, UD/SH3 DOMAIN, UD/SH3/SH2 DOMAIN.
Storage & Stability : Store vial at -20°Cto -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
PDB rendering based on 1a07. :

Gene Name : Src Rous sarcoma oncogene [ Mus musculus ]
Synonyms : Src ; Rous sarcoma oncogene; pp60c-src; AW259666
Gene ID : 20779
mRNA Refseq : NM_001025395
Protein Refseq : NP_001020566
UniProt ID : P05480
Chromosome Location : 2 89.0 cM
Pathway : Adherens junction; Endocytosis; ErbB signaling pathway; Focal adhesion; Gap junction; GnRH signaling pathway; Tight junction; VEGF signaling pathway
Function : ATP binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein domain specific binding; protein kinase activity; protein tyrosine kinase activity; transferase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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