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Recombinant Human Zeta-chain (TCR) Associated Protein Kinase 70kDa

Cat. No.: ZAP70-98H
Product Overview: Recombinant Human Zeta Chain Associated Protein Kinase 70 protein expressed inE.coliencodes C-terminal 130 amino acids and has a molecular mass of 40 kDa.
Description: Mutations in ZAP-70 gene results in a form of Severe Combined Immunodeficiency Syndrome (SCID) in humans. ZAP-70 expression also defines a subset of Chronic Lymphocytic Leukaemia (CLL) in patients with unmutated Ig gene and poor clinical course.
Source: Recombinant Human ZAP70 protein encoding C-terminal 130 amino acids expressed inE.coli.
Formulation: Recombinant Human ZAP70 C-terminal protein at 100µg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
Application And Suggested Dilutions: •ELISA •Inhibition Assays •Western Blotting.
Characterization: On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 40 kDa.
Storage & Stability: Store vial at -20°Cto -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Gene Name: ZAP70 zeta-chain (TCR) associated protein kinase 70kDa [ Homo sapiens ]
Synonyms: ZAP70; zeta-chain (TCR) associated protein kinase 70kDa; SRK; STD; TZK; ZAP-70; FLJ17670; FLJ17679; zeta-chain (TCR) associated protein kinase (70 kD); Tyrosine-protein kinase ZAP-70;70 kDa zeta-associated protein Syk-related tyrosine kinase; EC 2.7.10.2; zeta-chain associated protein kinase 70kDa; zeta-chain associated protein kinase, 70kD
Gene ID: 7535
mRNA Refseq: NM_001079
Protein Refseq: NP_001070
MIM: 176947
UniProt ID: P43403
Chromosome Location: 2q12
Pathway: Natural killer cell mediated cytotoxicity; Primary immunodeficiency; T cell receptor signaling pathway; Signaling in Immune system
Function: ATP binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phosphotyrosine binding; transferase activity; protein binding

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