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Recombinant Human Natural Cytotoxicity Triggering Receptor 1

Cat. No.: NCR1-166H
Product Overview: Recombinant Human NRNKp46 produced inE.Coliis a single, non-glycosylated polypeptide chain. The protein contains 235(22-255) amino acdis and has a molecular mass of 26.6 kDa. The protein is purified by FPLC gel-filtration chromatography.
Description: A natural cytotoxicity receptor (NCR) NKp46 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. The natural cytotoxicity receptors(NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. The three known NCRs include NKp46 and NKp30, which are expressed on circulating NKcells, and NKp44,which is expressed only on activating NK cells. NKp46 has been implicated in NK cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines. NKp46 has two extracellular Ig-like domains followed by a ~40 residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail.
Source: Escherichia Coli.
Amino Acid Sequence: MQQQTLPKPF IWAEPHFMVP KEKQVTICCQ GNYGAVEYQL HFEGSLFAVD RPKPPERINKVKFYIPDMNS RMAGQYSCIY RVGELWSEPS NLLDLVVTEM YDTPTLSVHP GPEVISGEEV TFYCRLDTAT SMFLLLKEGR SSHVQRGYGK VQAEFPLGPV TTAHRGTYRX FGSYNNHAWSFPSEPVKLLV TGDIENTSLA PEDPTFSADT WGTYLLTTET GLQKDHALWD HTAQN
Physical Appearance: Sterile filtered clorless solution.
Formulation: The protein (1mg/ml) contains phosphate buffered saline (pH7.4) & 1mM EDTA.
Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by reducing and non-reducing SDS-PAGE Coomassie.
Stability: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Gene Name: NCR1 natural cytotoxicity triggering receptor 1 [ Homo sapiens ]
Synonyms: NCR1; natural cytotoxicity triggering receptor 1; LY94; CD335; CD335 antigen; NKP46; NK-p46; FLJ99094; natural killer cell p46-related protein; lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46); lymphocyte antigen 94 (mouse) homolog (activating NK-receptor; NK-p46); Natural killer cell p46-related protein; hNKp46; NK-p46; NKp46; NK cell-activating receptor; Lymphocyte antigen 94 homolog
Gene ID: 9437
mRNA Refseq: NM_001145457
Protein Refseq: NP_001138929
MIM: 604530
UniProt ID: O76036
Chromosome Location: 19
Pathway: Natural killer cell mediated cytotoxicity
Function: protein binding; receptor activity; receptor signaling protein activity

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