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Recombinant Human FGFR1, Fc Chimera

Cat.No. : FGFR1-498H
Product Overview : Recombinant Human Fibroblast Growth Factor Receptor 1 encoding the signal peptide and extracellular domain of human Fibroblast Growth Factor Receptor 1 alpha (IIIc) (aa 1-363) was fused to the Fc region of human IgG1 (aa 93-330). The chimeric protein was expressed in modified human 293 cells.
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Cat. No. : FGFR1-498H
Description : Fibroblast growth factors (FGFs) belong to a large family (23 human members) of mitogenic factors that range in molecular mass from 17-34kDa. FGFs exhibit high affinity for heparin and heparin like glycosaminoglycans (HLGAGs), and these interactions are required for signaling activation from the FGF receptors.
Source : Human 293 cells.
Amino Acid Sequence : RPSPTLPEQAQPWGAPVEVESFLVH PGDLLQLRCRLRDDVQSINWLRDGV QLAESNRTRITGEEVEVQDSVPADS GLYACVTSSPSGSDTTYFSVNVSDA LPSSEDDDDDDDSSSEEKETDNTKP NRMPVAPYWTSPEKMEKKLHAVPAA KTVKFKCPSSGTPNPTLRWLKNGKE FKPDHRIGGYKVRYATWSIIMDSVV PSDKGNYTCIVENEYGSINHTYQLD VVERSPHRPILQAGLPANKTVALGS NVEFMCKVYSDPQPHIQWLKHIEVN GSKIGPDNLPYVQILKTAGVNTTDK EMEVLHLRNVSFEDAGEYTCLAGNS IGLSHHSAWLTVLEALEGIPKVDKK VEPKSCDKTHTCPPCPAPELLGGPS VFLFPPKPKDTLMISRTPEVTCVVV DVSHEDPEVKFNWYVDGVEVHNAKT KPREEQYNSTYRVVSVLTVLHQDWL NGKEYKCRVSNKALPAPIEKTISKA KGQPREPQVYTLPPSRDELTKNQVS LTCLVKGFYPSDIAVEWESNGQPEN NYKTTPPVLDSDGSFFLYSKLTVDK SRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK.
Molecular Mass : FGF R1 alpha (IIIc)-Fc Chimera migrates as a broad band between 100 and 130 kDa in SDS-PAGE due to post-translation modifications, in particular glycosylation.
pI : Due to post-translational modifications, in particular glycosylation, the Symansis FGF R1 alpha (IIIc)-Fc Chimera separates into multiple isoforms with a pI between 5.2 and 6.9 in 2D PAGE.
% Carbohydrate : Purified FGF R1 alpha (IIIc)-Fc Chimera consists of 35-50% carbohydrate (by wt).
Glycosylation : FGF R1 alpha (IIIc)-Fc Chimera has N-linked and probably O-linked oligosaccharides.
Purity : >95%, as determined by SDS-PAGE and visualized by silver stain.
Formulation : When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.
Storage : Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.
Gene Name : FGFR1 fibroblast growth factor receptor 1 [ Homo sapiens ]
Synonyms : FGFR1; fibroblast growth factor receptor 1; CEK; FLG; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; HBGFR; N-SAM; FLJ99988; OTTHUMP00000190881; soluble FGFR1 variant 1; FMS-like tyrosine kinase 2; ydroxyaryl-protein kinase; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; basic fibroblast growth factor receptor 1
Gene ID : 2260
mRNA Refseq : NM_015850
Protein Refseq : NP_056934
UniProt ID : P11362
Chromosome Location : 8p12
MIM : 136350
Pathway : Adherens junction; MAPK signaling pathway; elanoma; Pathways in cancer; Prostate cancer; Regulation of actin cytoskeleton; Axon guidance; Signaling by FGFR
Function : ATP binding; fibroblast growth factor receptor activity; heparin binding; nucleotide binding; protein binding; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does DEFB103A interact with the human microbiome? 06/10/2022

DEFB103A plays a role in maintaining a balanced microbiome by exerting selective antimicrobial activity. Understanding this interaction is crucial for potential applications in microbiome-related disorders.

Can DEFB103A be used as a diagnostic marker for certain diseases? 05/01/2022

Research suggests that altered levels of DEFB103A expression may be associated with certain diseases. However, its specific use as a diagnostic marker requires further validation.

Are there any side effects or concerns associated with the therapeutic use of DEFB103A? 04/25/2022

While research is ongoing, potential side effects and concerns related to the therapeutic use of DEFB103A or its analogs need to be thoroughly investigated, including any possible immunogenicity.

How does DEFB103A contribute to the immune system? 02/08/2018

DEFB103A plays a crucial role in the innate immune system by acting as an antimicrobial peptide. It helps defend the body against a wide range of pathogens, including bacteria, viruses, and fungi.

What specific clinical conditions are associated with DEFB103A deficiency? 05/25/2017

DEFB103A deficiency has been linked to an increased susceptibility to various infections, particularly those affecting the skin and mucosal surfaces.

Customer Reviews (3)

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Reviews
05/01/2021

    FGFR1, a calcium-dependent phospholipid-binding protein, plays a crucial role in various cellular processes, making it a valuable tool for investigation.

    12/25/2018

      When combined with the support and quality assurance provided by the manufacturer, researchers can confidently utilize FGFR1 protein to unravel the intricate mechanisms underlying cellular processes, ultimately advancing scientific knowledge.

      07/24/2017

        The manufacturer can contribute to the research process by providing top-quality FGFR1 protein that meets rigorous standards of purity, stability, and reliability.

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