Recombinant Human FGFR1, Fc Chimera FGFR1-498H

Recombinant Human FGFR1, Fc Chimera

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Recombinant Human FGFR1, Fc Chimera

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Cat. No. : FGFR1-498H
Product Overview : Recombinant Human Fibroblast Growth Factor Receptor 1 encoding the signal peptide and extracellular domain of human Fibroblast Growth Factor Receptor 1 alpha (IIIc) (aa 1-363) was fused to the Fc region of human IgG1 (aa 93-330). The chimeric protein was expressed in modified human 293 cells.
Description : Fibroblast growth factors (FGFs) belong to a large family (23 human members) of mitogenic factors that range in molecular mass from 17-34kDa. FGFs exhibit high affinity for heparin and heparin like glycosaminoglycans (HLGAGs), and these interactions are required for signaling activation from the FGF receptors.
Source : Human 293 cells.
Amino Acid Sequence : RPSPTLPEQAQPWGA PVEVESFLVHPGDLL QLRCRLRDDVQSINW LRDGVQLAESNRTRI TGEEVEVQDSVPADS GLYACVTSSPSGSDT TYFSVNVSDALPSSE DDDDDDDSSSEEKET DNTKPNRMPVAPYWT SPEKMEKKLHAVPAA KTVKFKCPSSGTPNP TLRWLKNGKEFKPDH RIGGYKVRYATWSII MDSVVPSDKGNYTCI VENEYGSINHTYQLD VVERSPHRPILQAGL PANKTVALGSNVEFM CKVYSDPQPHIQWLK HIEVNGSKIGPDNLP YVQILKTAGVNTTDK EMEVLHLRNVSFEDA GEYTCLAGNSIGLSH HSAWLTVLEALEGIP KVDKKVEPKSCDKTH TCPPCPAPELLGGPS VFLFPPKPKDTLMIS RTPEVTCVVVDVSHE DPEVKFNWYVDGVEV HNAKTKPREEQYNST YRVVSVLTVLHQDWL NGKEYKCRVSNKALP APIEKTISKAKGQPR EPQVYTLPPSRDELT KNQVSLTCLVKGFYP SDIAVEWESNGQPEN NYKTTPPVLDSDGSF FLYSKLTVDKSRWQQ GNVFSCSVMHEALHN HYTQKSLSLSPGK.
Molecular Mass : FGF R1 alpha (IIIc)-Fc Chimera migrates as a broad band between 100 and 130 kDa in SDS-PAGE due to post-translation modifications, in particular glycosylation.
pI : Due to post-translational modifications, in particular glycosylation, the Symansis FGF R1 alpha (IIIc)-Fc Chimera separates into multiple isoforms with a pI between 5.2 and 6.9 in 2D PAGE.
% Carbohydrate : Purified FGF R1 alpha (IIIc)-Fc Chimera consists of 35-50% carbohydrate (by wt).
Glycosylation : FGF R1 alpha (IIIc)-Fc Chimera has N-linked and probably O-linked oligosaccharides.
Purity : >95%, as determined by SDS-PAGE and visualized by silver stain.
Formulation : When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.
Storage : Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.
PDB rendering based on 1agw. :

Gene Name : FGFR1 fibroblast growth factor receptor 1 [ Homo sapiens ]
Synonyms : FGFR1; fibroblast growth factor receptor 1; CEK; FLG; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; HBGFR; N-SAM; FLJ99988; OTTHUMP00000190881; soluble FGFR1 variant 1; FMS-like tyrosine kinase 2; ydroxyaryl-protein kinase; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; basic fibroblast growth factor receptor 1
Gene ID : 2260
mRNA Refseq : NM_015850
Protein Refseq : NP_056934
UniProt ID : P11362
Chromosome Location : 8p12
MIM : 136350
Pathway : Adherens junction; MAPK signaling pathway; elanoma; Pathways in cancer; Prostate cancer; Regulation of actin cytoskeleton; Axon guidance; Signaling by FGFR
Function : ATP binding; fibroblast growth factor receptor activity; heparin binding; nucleotide binding; protein binding; transferase activity

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