"SAP18" Related Products

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Recombinant Human Sin3A-associated Protein, 18kDa

Cat. No.: SAP18-182H
Product Overview: Recombinant SAP18 protein was expressed inE.coliand purified by using conventional chromatography techniques. MW =19.7 kDa (173 aa).
Description: SAP18, also known as Sin3A-associated protein, is component of the histone deacetylase complex that plays an important role in the regulation of eukaryotic gene expression. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. It also has been shown to play a key role in gene-specific recruitment of the HDAC complex by a number of transcription factors including Gli, GAGA, and Bicoid.
Source: E.coli.
Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MAVESRVTQE EIKKEPEKPI DREKTCPLLL RVFTTNNGRH HRMDEFSRGN VPSSELQIYT WMDATLKELT SLVKEVYPEA RKKGTHFNFA IVFTDVKRPG YRVKEIGSTM SGRKGTDDSM TLQSQKFQIG DYLDIAITPP NRAPPPSGRM RPY
Form: Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 0.1M NaCl,
Purity: > 90% by SDS – PAGE.
Concentration: 0.5 mg/ml (determined by Bradford assay).
Endotoxin Level: < 1.0 EU per 1 μg of protein (determined by LAL method ).
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: SAP18 Sin3A-associated protein, 18kDa [ Homo sapiens ]
Synonyms: SAP18; Sin3A-associated protein, 18kDa; SAP18P; 2HOR0202; MGC27131; sin3-associated polypeptide, p18; cell growth inhibiting protein 38; histone deacetlyase complex subunit SAP18; sin3A-associated protein, 18kDa; SAP18p; Histone deacetylase complex subunit SAP18; Sin3-associated polypeptide, 18 kDa; Sin3-associated polypeptide p18; Cell growth-inhibiting protein 38; GIG38; OTTHUMP00000018107
Gene ID: 10284
mRNA Refseq: NM_005870
Protein Refseq: NP_005861
MIM: 602949
UniProt ID: O00422
Chromosome Location: 13q12.11
Function: protein binding; transcription corepressor activity

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