Recombinant Rhesus Interleukin 13
Cat.No. : | IL13-146R |
Product Overview : | Recombinant Rhesus Interleukin 13 encoding the Rhesus IL13 (NP_001028101.1) (Met 1 – Asn 132) precursor was expressed inCHO Cells. |
- Specification
- Gene Information
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Cat. No. : | IL13-146R |
Description : | Interleukin 13 (IL-13) is a single-chain cytokine which belongs to the IL13/IL4 family. In humans, IL13 is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL13 inhibits the production of pro-inflammatory cytokines and chemokines, and thus down-regulates macrophage activity. Meanwhile, IL-13 synergizes with IL2 in regulating IFN-gamma synthesis. IL-13 binds to a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains (IL13 Rα1 and IL13 Rα2), and exerts its effects through signal transducer and activator of transcription 6 (STAT6), like IL-4. Accordingly, IL-13 may be critical in regulating inflammatory and immune responses as a central mediator in various cell types. |
Molecular Mass : | The recombinant rhesus IL13 consists of 112 amino acids and has a calculated molecular mass of 12 kDa also estimated by SDS-PAGE under reducing conditions. |
Source : | CHO Cells. |
Predicted N Terminal : | Ser 21. |
Endotoxin : | < 1.0 EU per 1μg cytokine as determined by the LAL method. |
Formulation : | Supplied as a 0.2μm filtered solution of 20 mM Tris, 10 mM NaCl, pH 8.0. |
Reconstitution : | Follow the instructions on the vial. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Purity : | > 97%, as determined by SDS-PAGE. |
Stability : | Samples are stable for up to twelve months from date of receipt -70°C. |
Storage : | Store it under sterile conditions at -70°C. It is recommended that the protein be aliquoted for optimal storage and be used as soon as possible. Avoid repeated freeze-thaw cycles. |
Gene Name : | IL13 interleukin 13 [ Macaca mulatta ] |
Synonyms : | IL13; interleukin 13;interleukin-13 |
Gene ID : | 574325 |
mRNA Refseq : | NM_001032929 |
Protein Refseq : | NP_001028101 |
UniProt ID : | Q864V6 |
Pathway : | Asthma; Cytokine-cytokine receptor interaction; Fc epsilon RI signaling pathway; Jak-STAT signaling pathway |
Products Types
◆ Lysates | ||
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IL13-001HCL | Recombinant Human IL13 cell lysate | +Inquiry |
IL13-1894CCL | Recombinant Cynomolgus IL13 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionFlow cytometry quantifies IL13 receptor expression on cells.
Transgenic models illuminate IL13's in vivo functions.
ELISA quantifies IL13 secretion in cell cultures accurately.
siRNA knockdown uncovers IL13's specific cellular effects.
Co-immunoprecipitation identifies IL13 signaling partners.
Differential techniques distinguish IL13 and IL4 signaling pathways.
Reporter gene assays gauge IL13-driven transcription.
Microarray analysis profiles IL13-induced gene expression.
Experimental methods reveal IL13's impact on tissue remodeling.
Site-directed mutagenesis identifies key residues in IL13 receptor binding.
Customer Reviews (3)
Write a reviewEffective in Th2 cell differentiation.
Good for cytokine assays.
High yield in expression.
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