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Recombinant Rhesus Interleukin 13

Cat.No. : IL13-146R
Product Overview : Recombinant Rhesus Interleukin 13 encoding the Rhesus IL13 (NP_001028101.1) (Met 1 – Asn 132) precursor was expressed inCHO Cells.
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Cat. No. : IL13-146R
Description : Interleukin 13 (IL-13) is a single-chain cytokine which belongs to the IL13/IL4 family. In humans, IL13 is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL13 inhibits the production of pro-inflammatory cytokines and chemokines, and thus down-regulates macrophage activity. Meanwhile, IL-13 synergizes with IL2 in regulating IFN-gamma synthesis. IL-13 binds to a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains (IL13 Rα1 and IL13 Rα2), and exerts its effects through signal transducer and activator of transcription 6 (STAT6), like IL-4. Accordingly, IL-13 may be critical in regulating inflammatory and immune responses as a central mediator in various cell types.
Molecular Mass : The recombinant rhesus IL13 consists of 112 amino acids and has a calculated molecular mass of 12 kDa also estimated by SDS-PAGE under reducing conditions.
Source : CHO Cells.
Predicted N Terminal : Ser 21.
Endotoxin : < 1.0 EU per 1μg cytokine as determined by the LAL method.
Formulation : Supplied as a 0.2μm filtered solution of 20 mM Tris, 10 mM NaCl, pH 8.0.
Reconstitution : Follow the instructions on the vial. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Purity : > 97%, as determined by SDS-PAGE.
Stability : Samples are stable for up to twelve months from date of receipt -70°C.
Storage : Store it under sterile conditions at -70°C. It is recommended that the protein be aliquoted for optimal storage and be used as soon as possible. Avoid repeated freeze-thaw cycles.
Gene Name : IL13 interleukin 13 [ Macaca mulatta ]
Synonyms : IL13; interleukin 13;interleukin-13
Gene ID : 574325
mRNA Refseq : NM_001032929
Protein Refseq : NP_001028101
UniProt ID : Q864V6
Pathway : Asthma; Cytokine-cytokine receptor interaction; Fc epsilon RI signaling pathway; Jak-STAT signaling pathway

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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How does flow cytometry help quantify IL13 receptor expression on different cell populations? 12/29/2022

Flow cytometry quantifies IL13 receptor expression on cells.

What are the benefits of using transgenic animal models to study IL13's in vivo functions? 07/05/2022

Transgenic models illuminate IL13's in vivo functions.

Could you explain the role of ELISA in quantifying IL13 secretion levels in cell cultures? 02/23/2022

ELISA quantifies IL13 secretion in cell cultures accurately.

How can siRNA knockdown experiments reveal IL13's effects on specific cellular processes? 06/13/2021

siRNA knockdown uncovers IL13's specific cellular effects.

How does co-immunoprecipitation identify interacting partners in IL13-mediated signaling complexes? 07/28/2019

Co-immunoprecipitation identifies IL13 signaling partners.

What techniques can differentiate IL13-mediated signaling pathways from IL4 pathways? 07/23/2019

Differential techniques distinguish IL13 and IL4 signaling pathways.

Could you elaborate on the use of reporter gene assays to assess IL13-driven transcriptional activity? 12/16/2018

Reporter gene assays gauge IL13-driven transcription.

Can you describe the applications of microarray analysis in profiling IL13-induced gene expression changes? 11/14/2018

Microarray analysis profiles IL13-induced gene expression.

What experimental methods determine the impact of IL13 on tissue remodeling processes? 08/04/2018

Experimental methods reveal IL13's impact on tissue remodeling.

How does site-directed mutagenesis help identify critical residues in IL13 receptor binding? 07/04/2018

Site-directed mutagenesis identifies key residues in IL13 receptor binding.

Customer Reviews (3)

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Reviews
11/29/2021

    Effective in Th2 cell differentiation.

    04/22/2020

      Good for cytokine assays.

      01/26/2019

        High yield in expression.

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