Recombinant Human Neurturin

• Cat.No.: NRTN-953H
• Product Overview: Recombinant human Neurturin produced inE.Coliis a homodimeric 23.6 kDa protein consisting of two identical subunits each containing 103 amino acid residues.

Specification

• Cat. No.: NRTN-953H
• Description: Human Neurturin (NTN) and human GDNF comprise a family of TGF-beta related neurotrophic factor which have trophic influences on a variety of neuronal populations. Neurturin promotes the survivability of certain sympathetic and sensory neurons through interaction with distinct set of GDNF-like receptors.
• Source: E.Coli.
• Purity: 98 % (SDS-PAGE, HPLC).
• Endotoxin Level: < 0.1 ng per ug of Neurturin.
• Stabilizer: None.
• Formulation: Lyophilized.
• Biological Activity: Human Neurturin is fully biologically active when compared to standards. Human Neurturin at a concentration of 50-100 ng/ml will support the survival of 65% of newborn rat sympathetic neurons.
• Reconstitution: The lyophilized human Neurturin can be reconstituted in water to a concentration of 1 mg/ml. This solution can be diluted into other buffered solutions or stored at -20°C for future use. For most in vitro applications, Neurturin exerts its biological activity in the concentration of 0.1 to 10 ng/ml.
• Stability: The lyophilized protein, though stable at room temperature, is best stored desiccated below 0°C. Reconstituted Neurturin should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles.
• Pathways: Axon guidance

Gene Information

• Gene Name: NRTN neurturin [ Homo sapiens ]
• Synonyms: neurturin; NTN; NRTN
• Gene ID: 4902
• mRNA Refseq: NM_004558
• Protein Refseq: NP_004549
• MIM: 602018
• UniProt ID: Q99748
• Chromosome Location: 19p13.3
• Function: growth factor activity