Recombinant Human Transforming Growth Factor, Beta 1, His-tagged
Cat.No. : | TGFB1-908H |
Product Overview : | Recombinant Humantransforming growth factor, beta 1 encoding the human LAP/Prepro-transforming growth factor-beta 1 (Leu30-Arg278) was recombined with his tag at the N-Terminus. That was expressed inE.Coli, and purified by Ni-NTA column. MW=27.4.7KD. |
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Cat. No. : | TGFB1-908H |
Description : | Transforming growth factor beta 1 or TGF-β1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. |
Source : | E. Coli. |
Sequence : | Human LAP/Prepro-transforming growth factor-beta 1 (Leu30-Arg278).LSTCKTIDME LVKRKRIEAI RGQILSKLRL ASPPSQGEVP PGPLPEAVLA LYNSTRDRVA GESAEPEPEP EADYYAKEVT RVLMVETHNE IYDKFKQSTH SIYMFFNTSE LREAVPEPVL LSRAELRLLR LKLKVEQHVE LYQKYSNNSW RYLSNRLLAP SDSPEWLSFD VTGVVRQWLS RGGEIEGFRL SAHCSCDSRD NTLQVDINGF TTGRRGDLAT IHGMNRPFLL LMATPLERAQ HLQSSRHRR. |
Purity : | >95% in SDS gel. |
Formulation : | Lyophilized 100 μg human LAP/Prepro-transforming growth factor-beta 1in 50 μl of TBS ( 20 mM Tris, 50mM NaCl, pH8.0 ). Carry free. |
Reconstitution : | Add 500μl deionized water to the vial to prepare a working stock solution at 200 μg/mL. Allow to set at least 30 minutes at 4℃, mix well. |
Application : | Cell biology, ELISA. |
Storage : | Store lyophilized protein at -20℃ to -70℃. Lyophilized protein is stable for up to 6 months from date of receipt at - 20℃ to -70℃. Upon reconstitution, this protein can be stored at -20℃ for up to a few weeks or at -70℃ in a manual defrost freezer for long term storage (six months). Aliquot reconstituted protein to avoid repeated freeze / thaw cycles. |
Gene Name : | TGFB1 transforming growth factor, beta 1 [ Homo sapiens ] |
Synonyms : | TGFB1; transforming growth factor, beta 1; CED; LAP; DPD1; TGFB; TGFbeta; TGF-beta 1 protein; latency-associated peptide; Camurati-Engelmann disease; Transforming growth factor beta-1; TGF-beta-1; Latency-associated peptide; LAP |
Gene ID : | 7040 |
mRNA Refseq : | NM_000660 |
Protein Refseq : | NP_000651 |
MIM : | 190180 |
UniProt ID : | P01137 |
Chromosome Location : | 19q13.1 |
Pathway : | Cell cycle; Chronic myeloid leukemia; Colorectal cancer; Cytokine-cytokine receptor interaction; Hypertrophic cardiomyopathy (HCM); MAPK signaling pathway; Pancreatic cancer; Pathways in cancer; Renal cell carcinoma; TGF-beta signaling pathway; Hemostasis; Influenza Infection; Signaling by TGF beta |
Function : | growth factor activity; protein N-terminus binding; protein heterodimerization activity; protein homodimerization activity; transcription activator activity; type II transforming growth factor beta receptor binding; type II transforming growth factor beta receptor binding |
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◆ Native Protein | ||
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◆ Lysates | ||
TGFB1-2662HCL | Recombinant Human TGFB1 cell lysate | +Inquiry |
TGFB1-001HCL | Recombinant Human TGFB1 cell lysate | +Inquiry |
TGFB1-001MCL | Recombinant Mouse TGFB1 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionTGFB1 stimulates the activity of cells involved in bone formation (osteoblasts) and plays a role in regulating bone resorption by influencing osteoclast function.
Potential side effects of anti-TGFB1 therapies may include immune system suppression, gastrointestinal issues, and skin reactions.
TGFB1 levels have been studied as potential biomarkers for diseases like cancer and fibrosis, aiding in diagnosis and monitoring disease progression.
TGFB1 plays a critical role in wound healing by stimulating the formation of new blood vessels, promoting the production of extracellular matrix, and aiding in the migration of cells to the wound site.
TGFB1 can induce the production of excessive extracellular matrix proteins, leading to tissue scarring and fibrosis in organs such as the liver, lung, and kidneys.
Customer Reviews (3)
Write a reviewThe impressive performance of the TGFB1 protein both in ELISA assays and protein electron microscopy structure analysis makes it a highly versatile and recommended choice for scientists across various disciplines.
Its reliability and efficacy in generating high-quality data make it an indispensable tool in the quest for unraveling the mysteries of protein structure and function.
The TGFB1 protein's excellent performance in ELISA ensures accurate and reproducible results, enhancing the reliability of experimental data.
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