"PYCR1" Related Products

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Pyrroline-5-carboxylate Reductase 1

Cat. No.: CBCRY27
Background: Pyrroline-5-carboxylate reductase (P5CR) is a universal housekeeping enzyme that catalyzes the reduction of Delta(1)-pyrroline-5-carboxylate (P5C) to proline using NAD(P)H as the cofactor. The enzymatic cycle between P5C and proline is very important for the regulation of amino acid metabolism, intracellular redox potential, and apoptosis.
Protein Classification: Oxidoreductase
Structure Weight: 168155.50 Da
Polymer: 1
Molecule: Pyrroline-5-carboxylate reductase 1
Chain Length: 321 amino acids
PDB ID: 2GER
MMDB ID: 41542
Source: E.coli
Method: X-Ray Diffraction
Resolution: 3.1Å
Reference: Meng, Z., Lou, Z., Liu, Z., Li, M., Zhao, X., Bartlam, M., Rao, Z. (2006) Crystal structure of human pyrroline-5-carboxylate reductase J.Mol.Biol. 359: 1364-1377
Gene Name: PYCR1
Synonyms: P5C; P5CR; PIG45; PP222; PYCR; P5C reductase; proliferation-inducing protein 45; pyrroline-5-carboxylate reductase 1; EC 1.5.1.2; P5C reductase 1; P5CR1
UniProt ID: P32322
Gene ID: 5831
Chromosome Location: 17q25.3
Function: binding; oxidoreductase activity; pyrroline-5-carboxylate resuctase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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