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Recombinant Human S100A6, His-tagged

Cat. No.: S100A6-916H
Product Overview: Recombinant Human S100A6 encoding the human mature S100A6 (Met1-Gly90) with 6 His tag on the N-Terminus was expressed inE. Coli. This protein was purified by Ni-NTA column. MW = 12 KD.
Description: S100A6 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.
Source: Escherichia Coli.
Amino Acid Sequence: human mature S100A6 (Met1-Gly90). MACPLDQAIG LLVAIFHKYS GREGDKHTLS KKELKELIQK ELTIGSKLQD AEIARLMEDL DRNKDQEVNF QEYVTFLGAL ALIYNEALKG 90.
Application: Cell biology.
Purity: >95% in SDS gel.
Formulation: Lyophilized 100 μg human mature S100A6 in 50 μl of TBS ( 20 mM Tris, 50mM NaCl,pH8.0 ). Carry free.
Reconstitution: Add 500 μl deionized water or TBS to the vial to prepare a working stock solution at 200 μg/mL . Allow to set at least 30 minutes at 4° C, mix well.
Storage: Store lyophilized protein at -20 °C or -70 °C. Lyophilized protein is stable for up to 6 months from date of receipt at - 20 °C to -70 °C. Upon reconstitution, this protein can be stored at -20 °C for a few weeks or at -70 °C in a manual defrost freezer for long term storage (six months). Aliquot reconstituted protein to avoid repeated freezing / thawing cycles.
Gene Name: S100A6 S100 calcium binding protein A6 [ Homo sapiens ]
Synonyms: S100 calcium binding protein A6; 2A9; PRA; 5B10; CABP; CACY; S100A6; calcyclin; OTTHUMP00000015473; prolactin receptor-associated protein; S100 calcium-binding protein A6 (calcyclin); Calcyclin; OTTHUMP00000015472; Growth factor-inducible protein 2A9; MLN 4; Prolactin receptor-associated protein; S100 calcium-binding protein A6; S100 calcium binding protein A6 (calcyclin)
Gene ID: 6277
mRNA Refseq: NM_014624
Protein Refseq: NP_055439
MIM: 114110
UniProt ID: P06703
Chromosome Location: 1q21
Function: ion transmembrane transporter activity; protein homodimerization activity; calcium-dependent protein binding; S100 beta binding; calcium ion binding zinc ion binding

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