"USP7" Related Products


Ubiquitin Carboxyl-terminal Hydrolase 7

Cat. No.: CBCRY35
Background: Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7), a deubiquitylating enzyme of the ubiquitin-specific processing protease family, specifically deubiquitylates both p53 and MDM2, hence playing an important yet enigmatic role in the p53-MDM2 pathway.
Protein Classification: Hydrolase
Structure Weight: 121067.00 Da
Polymer: 1
Molecule: Ubiquitin carboxyl-terminal hydrolase 7
Chain Length: 522 amino acids
MMDB ID: 37695
Source: E.coli
Method: X-Ray Diffraction
Resolution: 3.2Å
Reference: Hu, M., Gu, L., Li, M., Jeffrey, P.D., Gu, W., Shi, Y. (2006) Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway. Plos Biol. 4: e27-e27
Gene Name: USP7
Synonyms: HAUSP; TEF1; EC; Herpes virus-associated ubiquitin-specific protease; ubiquitin specific peptidase 7; ubiquitin specific protease 7 (herpes virus-associated); deubiquitinating enzyme 7; Ubiquitin thioesterase 7
UniProt ID: Q93009
Gene ID: 7874
Chromosome Location: 16p13.3
Function: cysteine-type endopeptidase activity; ubiquitin thiolesterase activity; protein binding; protein C-terminus binding; peptidase activity; cysteine-type peptidase activity; hydrolase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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